阿仑膦酸钠联合阿托伐他汀治疗糖尿病合并骨质疏松的效果分析  

Effect analysis of alendronate sodium combined with atorvastatin in the treatment of diabetes mellitus complicated with osteoporosis

作　　者：古东海[1] 李子怡 庞若宇 GU Dong-hai;LI Zi-yi;PANG Ruo-yu(Maoming People's Hospital,Maoming 525000,China)

机构地区：[1]茂名市人民医院,525000

出　　处：《中国实用医药》2022年第23期25-28,共4页China Practical Medicine

摘　　要：目的 分析阿仑膦酸钠联合阿托伐他汀治疗糖尿病合并骨质疏松的效果。方法 30例糖尿病合并骨质疏松患者,随机分为对照组及试验组,每组15例。对照组应用二甲双胍+阿仑膦酸钠治疗,试验组应用二甲双胍+阿仑膦酸钠+阿托伐他汀治疗。对比两组治疗前后的骨密度、骨代谢指标[骨保护素(OPG)、骨源性碱性磷酸酶(NBAP)及骨钙素N端中分子(N-MID)]以及血糖[空腹血糖、餐后2 h血糖及糖化血红蛋白]水平。结果 治疗后,试验组前臂、股骨粗隆、股骨颈以及腰椎正位的骨密度分别为(0.75±0.03)、(0.75±0.09)、(0.75±0.13)、(0.78±0.06)g/cm^(2),均高于对照组的(0.68±0.05)、(0.69±0.06)、(0.65±0.09)、(0.67±0.03)g/cm^(2),差异具有统计学意义(P<0.05)。治疗后,试验组NBAP、OPG以及N-MID水平分别为(16.82±3.17)μg/L、(49.85±4.28)pg/ml、(18.74±3.62)ng/ml,高于对照组的(12.47±2.16)μg/L、(43.11±4.02)pg/ml、(13.29±2.68)ng/ml,差异具有统计学意义(P<0.05)。治疗前后,两组空腹血糖、餐后2 h血糖以及糖化血红蛋白水平对比,差异均无统计学意义(P>0.05)。结论 阿仑膦酸钠+阿托伐他汀治疗糖尿病合并骨质疏松的效果良好,对于患者骨密度的改善具有促进作用,且不会增加高血糖的风险。Objective To analyze the effect of alendronate sodium combined with atorvastatin in the treatment of diabetes mellitus complicated with osteoporosis.Methods A total of 30 patients with diabetes mellitus and osteoporosis were randomly divided into control group and experimental group,with 15 cases in each group.The control group was treated with metformin+alendronate sodium,and the experimental group was treated with metformin+alendronate sodium+atorvastatin.Both groups were compared in terms of bone mineral density,bone metabolism indexes[osteoprotegerin(OPG),bone-derived alkaline phosphatase(NBAP)and molecular fragment of osteocalcin N terminal(N-MID)],blood glucose[fasting blood glucose,2-h postprandial blood glucose and glycated hemoglobin]levels before and after treatment.Results After treatment,the BMD of the forearm,femoral tuberosity,femoral neck and lumbar spine in the experimental group were(0.75±0.03),(0.75±0.09),(0.75±0.13)and(0.78±0.06)g/cm^(2),which were higher than(0.68±0.05),(0.69±0.06),(0.65±0.09)and(0.67±0.03)g/cm^(2) in the control group,and the differences were all statistically significant(P<0.05).After treatment,the levels of NBAP,OPG and N-MID in the experimental group were(16.82±3.17)μg/L,(49.85±4.28)pg/ml and(18.74±3.62)ng/ml,which were higher than(12.47±2.16)μg/L,(43.11±4.02)pg/ml and(13.29±2.68)ng/ml in the control group,and the differences were all statistically significant(P<0.05).Before and after treatment,the differences in levels of fasting blood glucose,2-h postprandial blood glucose and glycated hemoglobin between the two groups were not statistically significant(P>0.05).Conclusion Alendronate sodium+atorvastatin has a good effect in the treatment of diabetes mellitus with osteoporosis.It can promote the improvement of patients'bone mineral density without increasing the risk of hyperglycemia.

关 键 词：糖尿病合并骨质疏松 阿仑膦酸钠 阿托伐他汀 骨密度 

分 类 号：R580[医药卫生—内分泌] R587.1[医药卫生—内科学]