前列地尔治疗慢性肾功能衰竭的效果及对肾功能指标的影响分析  

Analysis of the effect of alprostadil in the treatment of chronic renal failure and its influence on renal function indexes

作　　者：管丽艳 GUAN Li-yan(Donggang Municipal Hospital of Traditional Chinese Medicine,Dandong 118300,China)

机构地区：[1]东港市中医院,118300

出　　处：《中国实用医药》2022年第23期142-144,共3页China Practical Medicine

摘　　要：目的 研究慢性肾功能衰竭患者应用前列地尔的效果及对患者肾功能指标的影响。方法 68例慢性肾功能衰竭患者,根据电脑随机方式分为参照组及实验组,每组34例。参照组给予常规治疗,实验组在参照组基础上给予前列地尔治疗。对比两组肾功能指标(血肌酐、24 h尿蛋白定量、血尿素氮)、炎性因子(白细胞介素-6、C反应蛋白、肿瘤坏死因子-α)水平以及不良反应发生情况。结果 实验组血肌酐、24 h尿蛋白定量、血尿素氮分别为(278.63±51.48)μmol/L、(1.32±0.84)g/24 h、(14.72±3.58)mmol/L,均低于参照组的(335.26±62.31)μmol/L、(2.29±1.23)g/24 h、(20.58±4.32)mmol/L,差异具有统计学意义(P<0.05)。实验组白细胞介素-6、C反应蛋白、肿瘤坏死因子-α水平分别为(16.35±5.24)pg/ml、(7.23±2.48)mg/L、(14.23±4.17)pg/ml,均低于参照组的(24.85±5.36)pg/ml、(10.18±3.23)mg/L、(18.79±4.28)pg/ml,差异具有统计学意义(P<0.05)。实验组不良反应发生率5.88%低于参照组的23.53%,差异具有统计学意义(P<0.05)。结论 使用前列地尔治疗慢性肾功能衰竭时能够有效地改善患者的炎性因子水平,促进肾功能的恢复,减少不良反应的发生,安全性更高,值得推广和使用。Objective To study the effect of alprostadil in the treatment of chronic renal failure and its influence on renal function indexes.Methods A total of 68 patients with chronic renal failure were randomly divided into reference group and experimental group by computer random method,with 34 cases in each group.The reference group was treated with conventional therapy,and the experimental group was treated with alprostadil on the basis of the reference group.Both groups were compared in terms of renal function indexes(serum creatinine,24-h urinary protein quantification,blood urea nitrogen),inflammatory factors(interleukin-6,C-reactive protein,tumor necrosis factor-α),and occurrence of adverse reactions.Results The serum creatinine,24-h urinary protein quantification and blood urea nitrogen in the experimental group were(278.63±51.48)μmol/L,(1.32±0.84)g/24 h and(14.72±3.58)mmol/L,which were lower than(335.26±62.31)μmol/L,(2.29±1.23)g/24 h and(20.58±4.32)mmol/L in the reference group,and the differences were all statistically significant(P<0.05).The levels of interleukin-6,C-reactive protein,and tumor necrosis factor-αin the experimental group were(16.35±5.24)pg/ml,(7.23±2.48)mg/L,and(14.23±4.17)pg/ml,which were lower than(24.85±5.36)pg/ml,(10.18±3.23)mg/L,and(18.79±4.28)pg/ml in the reference group,and the differences were all statistically significant(P<0.05).The incidence of adverse reactions 5.88%in the experimental group was lower than 23.53%in the reference group,and the difference was statistically significant(P<0.05).Conclusion The use of alprostadil for the treatment of chronic renal failure can effectively improve the level of inflammatory factors in patients,promote the recovery of renal function,reduce the occurrence of adverse reactions with high safety,which is worthy of promotion and application,

关 键 词：前列地尔 慢性肾功能衰竭 肾功能指标 

分 类 号：R692.5[医药卫生—泌尿科学]