小剂量左甲状腺素治疗良性甲状腺结节的疗效分析  

Efficacy analysis of low-dose levothyroxine on benign thyroid nodules

作　　者：李瑷 LI Ai(Tieling Central Hospital,Tieling 112000,China)

机构地区：[1]铁岭市中心医院,112000

出　　处：《中国实用医药》2022年第23期157-159,共3页China Practical Medicine

摘　　要：目的 分析小剂量左甲状腺素治疗良性甲状腺结节的临床疗效。方法 90例良性甲状腺结节患者,依据随机数字表法分为观察组与对照组,各45例。对照组饭前口服消瘿丸治疗,观察组在对照组基础上给予小剂量左甲状腺素治疗。比较两组甲状腺功能状况恢复正常时间、甲状腺结节消失时间,治疗前后患者血清游离三碘甲状腺原氨酸、游离四碘甲状腺原氨酸、促甲状腺激素水平,治疗效果及不良反应发生情况。结果 观察组甲状腺功能状况恢复正常时间(6.34±1.21)d、甲状腺结节消失时间(5.25±1.21)d均短于对照组的(9.55±2.51)、(8.50±2.22)d,差异有统计学意义(P<0.05)。治疗后,两组血清游离三碘甲状腺原氨酸、游离四碘甲状腺原氨酸、促甲状腺激素均优于本组治疗前,且观察组显著优于对照组,差异均有统计学意义(P<0.05)。观察组治疗总有效率95.56%高于对照组的71.11%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论 小剂量左甲状腺素治疗良性甲状腺结节的效果确切,可有效改善患者的甲状腺功能,安全性高,是一种值得推广的治疗方式。Objective To analyze the clinical efficacy of low-dose levothyroxine on benign thyroid nodules.Methods A total of 90 patients with benign thyroid nodules were divided into observation group and control group according to random numerical table,with 45 cases in each group.The control group was given Xiaoying Pills orally before meals,and the observation group was given low-dose levothyroxine on the basis of the control group.Both groups were compared in terms of recovery time of thyroid function,disappearance time of thyroid nodules,serum free triiodothyronine,free tetraiodothyronine and thyroid stimulating hormone before and after treatment,therapeutic effect,and occurrence of adverse reactions.Results The recovery time of thyroid function(6.34±1.21)d,and disappearance time of thyroid nodules(5.25±1.21)d in the observation group were shorter than(9.55±2.51)and(8.50±2.22)d in the control group,and the differences were all statistically significant(P<0.05).After treatment,the serum free triiodothyronine,free tetraiodothyronine and thyroid stimulating hormone in the two groups were better than those before treatment in this group,and the observation group was significantly better than the control group.The differences were all statistically significant(P<0.05).The total effective rate 95.56%of the observation group was higher than 71.11%of the control group,and the difference was statistically significant(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Low-dose levothyroxine has definite effect in the treatment of benign thyroid nodules,and can effectively improve the thyroid function of patients with high safety,which is a treatment worthy of promotion.

关 键 词：小剂量左甲状腺素 良性甲状腺结节 临床疗效 

分 类 号：R581[医药卫生—内分泌]