慢性阻塞性肺疾病患者血清维生素D与炎性指标的相关性分析  

Clinical study on the correlation between vitamin D and inflammatory indicators in COPD patients

作　　者：周丽 刘旭春[1] ZHOU Li;LIU Xuchun(Department of Geriatrics,Chizhou people’s Hospital Affiliated to Wannan Medical College,Chizhou,Anhui 247100,China)

机构地区：[1]池州市人民医院老年医学科,安徽池州247100

出　　处：《医药前沿》2022年第25期43-45,共3页Journal of Frontiers of Medicine

基　　金：2021年度安徽省卫生健康委科研项目(AHWJ2021b106)。

摘　　要：目的:分析慢性阻塞性肺疾病(COPD)患者血清25-羟维生素D[25-(OH)D]与炎性指标之间的相关性。方法:选取2020年10月—2022年2月池州市人民医院收治的COPD患者113例为COPD组,并纳入同期健康体检者72例为健康组。参照GOLD-2017中的COPD诊断及分组标准将COPD组进一步分为C组和D组,比较C组和D组25-(OH)D、C反应蛋白(CRP)、中性粒细胞百分比(N%)、白介素-6(IL-6)、血清淀粉样蛋白A(SAA)水平差异,并进行相关性分析。结果:COPD组患者25-(OH)D水平低于健康组。COPD患者中D组25-羟维生素D低于C组,差异有统计学意义(P<0.05);而CRP、N%、IL-6、SAA水平高于C组,差异有统计学意义(P<0.05)。Pearson相关性分析显示,COPD患者血清25-(OH)D水平与CRP、N%、IL-6、SAA均呈负相关(P<0.05)。结论:COPD患者血清25-(OH)D明显低于健康人群,且与CRP、N%、IL-6、SAA存在负性相关性。血清25-(OH)D可单独或联合上述炎性指标作为判断COPD病情的潜在生物学指标。Objective To analysis the correlation between serum 25-hydroxyvitamin D and related inflammatory indicators in patients with chronic obstructive pulmonary disease(COPD).Methods Serum 25-hydroxyvitamin D levels were compared between COPD group and the healthy group.The COPD group was further divided into group C and group D according to the severity of the disease.The levels of 25-hydroxyvitamin D,CRP,N%,IL-6 and SAA between the two groups were compared,and the correlation between 25-hydroxyvitamin D and CRP,N%,IL-6 and SAA was analyzed.Results The level of 25 hydroxyvitamin D in COPD group was lower than that in healthy group(P<0.05).In COPD patients,25 hydroxyvitamin D in group D was lower than that in group C(P<0.05),while CRP,N%,IL-6 and SAA were higher than those in group C(P<0.05).Pearson correlation analysis showed that there was a significant negative correlation between 25-hydroxyvitamin D and CRP,N%,IL-6,and SAA in COPD patients(P<0.05).Conclusion Serum 25-hydroxyvitamin D was significantly lower in COPD patients than that in healthy people,and showed a negative correlation with CRP,N%,IL-6,and SAA.Serum 25-hydroxyvitamin D may be used alone or in combination with the abovementioned inflammatory mediators as a potential biological indicator for determining the condition of COPD patients.

关 键 词：慢性阻塞性肺疾病 25-羟维生素D 炎性指标 

分 类 号：R563[医药卫生—呼吸系统]