谷氨酰胺强化肠内营养支持应用于老年晚期胃癌病人治疗中的有效性观察  

Efficacy of glutamine intensive enteral nutrition support in elderly patients with advanced gastric cancer

作　　者：杨奕轩[1] 陈青怡 Yang Yixuan;Chen Qingyi(Department of Cadre Health Care,The First Affiliated Hospital of Xiamen University,Xiamen 361005)

机构地区：[1]厦门大学附属第一医院干部保健二科,厦门361005

出　　处：《数理医药学杂志》2022年第11期1723-1725,共3页Journal of Mathematical Medicine

摘　　要：目的:探讨谷氨酰胺强化肠内营养支持应用于老年晚期胃癌患者治疗中的效果。方法:选取本院2019年2月-2022年2月诊治的98例老年晚期胃癌患者,依照随机数字表法分为两组,对照组(49例)采用常规营养支持方案,观察组(49例)另外给予谷氨酰胺强化肠内营养支持,比较两组临床效果。结果:治疗后,观察组红细胞、白蛋白、前白蛋白高于对照组(P<0.05);观察组免疫球蛋白(Ig)G、IgA、IgM高于对照组(P<0.05);观察组降钙素原、D-乳酸、尿乳果糖/甘露醇比值(L/M)、血浆二胶氧化酶(DAO)低于对照组,血浆谷氨酰胺浓度高于对照组(P<0.05);两组不良反应发生情况比较(P>0.05)。结论:谷氨酰胺强化肠内营养支持可改善老年晚期胃癌患者的营养状态与免疫功能,降低疾病及治疗对肠黏膜屏障功能的影响,临床效果显著。Objective: To investigate the effect of glutamine enhanced enteral nutrition support in the treatment of elderly patients with advanced gastric cancer. Methods: A total of 98 elderly patients with advanced gastric cancer diagnosed and treated in our hospital from February 2019 to February 2022 were selected and divided into two groups according to the random number table method. The control group(n=49) was given conventional nutritional support program, and the observation group(n=49) was additionally given glutamine intensive enteral nutrition support. The clinical effects of the two groups were compared. Results: After treatment. The erythrocyte, albumin and prealbumin levels in the observation group were higher than those in the control group(P<0.05). After treatment. The immunoglobulin(Ig)G, IgA and IgM of the observation group were higher than those of the control group(P<0.05). After treatment. The procalcitonin, D-lactic acid, urine lactulose/mannitol ratio(L/M) and plasma dimucin oxidase(DAO) in the observation group were lower than those in the control group, and the plasma glutamine concentration was higher than that in the control group(P<0.05). The incidence of adverse reactions was compared between the two groups(P>0.05).Conclusion: Glutamine enhanced enteral nutrition support can improve the nutritional status and immune function of elderly patients with advanced gastric cancer, and reduce the effect of disease and treatment on intestinal mucosal barrier function, with significant clinical effect.

关 键 词：谷氨酰胺 营养支持 胃癌 营养指标 肠黏膜屏障功能 免疫功能指标 

分 类 号：R473.5[医药卫生—护理学]