慢性心力衰竭合并2型糖尿病患者血清生长分化因子-15和胱抑素C的变化  

Changes of Serum Growth Differentiation Factor-15 and Cystatin C in Patients with Chronic Heart Failure and Type 2 Diabetes

作　　者：胡美玲 顾明[1] HU Meiling;GU Ming(Affiliated Hospital of Beihua University,Jilin 132011,China)

机构地区：[1]北华大学附属医院,吉林吉林132011

出　　处：《北华大学学报（自然科学版）》2022年第5期616-619,共4页Journal of Beihua University（Natural Science）

基　　金：吉林省教育厅科学技术研究项目(2015140).

摘　　要：目的探讨慢性心力衰竭(chronic heart failure,CHF)合并2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清中生长分化因子-15(GDF-15)和胱抑素C(Cys-C)的变化情况.方法选取54例CHF合并T2DM患者为试验组,54例CHF不合并T2DM患者为对照组,采用酶联免疫吸附法中双抗体夹心法测定GDF-15在两组患者中的含量,同时检测Cys-C水平,联合GDF-15与Cys-C检测结果对CHF合并T2DM的患者的病情进行评估.结果试验组患者血清GDF-15和Cys-C水平高于对照组(P<0.05),两组患者血清中GDF-15与Cys-C水平随心功能分级程度的加重而升高.结论GDF-15与Cys-C在CHF合并T2DM患者血清中呈高表达趋势,GDF-15与Cys-C的联合检测有望成为CHF合并T2DM早期诊断的血清学标志物.Objective To investigate the changes of serum growth differentiation factor-15(GDF-15)and cystatin C(Cys-C)in patients with chronic heart failure(CHF)and type 2 diabetes mellitus(T2DM).Method 54 patients with CHF combined with T2DM were selected as the experimental group and 54 patients without CHF combined with T2DM as the control group.The expression of GDF-15 in the two groups was measured by double antibody sandwich method in enzyme-linked immunosorbent assay.At the same time,the level of Cys-C was obtained by laboratory test results.Patients with CHF combined with T2DM was evaluated by combining GDF-15 and Cys-C results.Results The level of serum GDF-15 in the experimental group was significantly higher that that in the control group(P<0.05).The levels of GDF-15 and Cys-C of serum in the two groups increased with the aggravation of functional grading,and there was a positive correlation trend.Conclusion GDF-15 and Cys-C are highly expressed in the serum of patients with CHF complicated with T2DM.GDF-15 and Cys-C are expected to become serological markers for the early diagnosis of CHF complicated with T2DM.

关 键 词：慢性心力衰竭 2型糖尿病 生长分化因子-15 血清胱抑素C 心功能分级 

分 类 号：R541.6[医药卫生—心血管疾病]