基于VW-MRI的颅内动脉粥样硬化斑块与胚胎型大脑后动脉的相关性研究  

Correlation between intracranial atherosclerotic plaque and fetal-type posterior cerebral artery based on VW-MRI

作　　者：刘丁琦 赵登玲[1] 陈晓晖[1] 李澄[1] LIU Ding-qi;ZHAO Deng-ling;CHEN Xiao-hui(Department of Radiology,Zhongda Hospital,School of Medical,Southeast University,Nanjing 210009,China)

机构地区：[1]东南大学附属中大医院放射科,南京210009

出　　处：《放射学实践》2022年第11期1347-1352,共6页Radiologic Practice

基　　金：江苏省卫生计生委项目(H2017008);江苏省自然科学基金(青年基金)(BK20170704)。

摘　　要：目的:基于磁共振血管壁成像(VW-MRI)技术研究颅内动脉粥样硬化斑块与胚胎型大脑后动脉(FTP)的相关性。方法:搜集2018年10月-2022年4月在东南大学附属中大医院行VW-MRI检查的所有患者的病例资料。将有动脉粥样硬化斑块的患者分为FTP组(n=40)和非FTP组(n=67)。比较两组大脑中动脉和椎基底动脉斑块分布特点及血管的狭窄程度、重构指数和偏心指数。结果:共纳入107名患者,FTP组大脑中动脉斑块较非FTP组更好发于血管的背侧壁及上壁(37.5%vs.16.42%),更容易发生正性重构(1.071±0.267 vs.0.877±0.232),两组差异有统计学意义(P<0.05)。调整混杂因素后,重构指数与FTP仍然具有相关性(95%CI:1.433~687.143;P=0.029)。两组患者椎基底动脉斑块分布(17.5%vs.8.96%,10%vs.11.94%,20%vs.17.91%)及血管特征(重构指数:1.095±0.347 vs.0.982±0.247;偏心指数:0.539±1.622 vs.0.551±0.167)差异无统计学意义(P>0.05)。结论:FTP组斑块更好发于大脑中动脉的背侧壁和上壁,FTP对大脑中动脉粥样硬化斑块的发展和血管正性重构具有一定的影响。Objective:To quantitatively analyze the relationship between fetal-type posterior artery and intracranial anterior and posterior circulating atherosclerotic plaques using VW-MRI.Methods:A total of 107 patients(40 patients with fetal-type posterior artery and 67 patients without fetal-type posterior artery)were included for 3.0T VW-MRI scan analysis.The images of the MCA and VBA vessel wall on VW-MRI were compared between the two groups based on the distribution,the degree of stenosis,remodeling index,and eccentricity degree.Results:The plaques of MCA in FTP group were more likely to occur on the posterior and superior wall of lumen compared with the non-FTP group(37.5%vs.16.42%,P<0.05).Positive remodeling of MCA plaque was more frequently observed in FTP group than in non-FTP group(1.071±0.267 vs.0.877±0.232,P<0.05).Remodeling index was associated with FTP after adjustment for the confounding factors(95%CI,1.433~687.143;P=0.029).No significant differences were found in VBA plaque distribution(17.5%vs.8.96%,10%vs.11.94%,20%vs.17.91%,P>0.05)and characteristics between the two groups(remodeling Index:1.095±0.347 vs.0.982±0.247;eccentricity index:0.539±1.622 vs.0.551±0.167,P>0.05).Conclusion:The plaques in FTP group are more likely to occur in the dorsal and upper walls of the MCA,and FTP has a certain influence on the development of MCA atherosclerotic plaques and positive vascular remodeling.

关 键 词：胚胎型大脑后动脉 动脉粥样硬化 斑块 磁共振血管壁成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R543.5[医药卫生—诊断学]