APT定量参数与直肠癌病理类型及分期的相关性  

Correlation of APT quantitative parameter with histopathological type and clinical stage in rectal carcinoma

作　　者：李娟[1] 高雪梅[1] 程敬亮[1] LI Juan;GAO Xue-mei;CHENG Jing-liang(Department of MRI,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院磁共振科,郑州450052

出　　处：《放射学实践》2022年第11期1405-1409,共5页Radiologic Practice

摘　　要：目的:探讨酰胺质子转移(APT)成像定量参数和直肠癌病理类型、分期的相关性。方法:以94例病理证实为直肠癌的患者为研究对象,所有患者均行高分辨MRI、APT成像及扩散加权成像(DWI),测量不同组织病理类型、分级、分期以及相关结构侵犯状态的APT信号强度(APT SI)及表观扩散系数(ADC),并进行统计学分析。结果:直肠黏液腺癌APT SI、ADC值高于普通腺癌,差异具有统计学意义(P<0.001);低级别普通腺癌APT SI低于高级别普通腺癌,差异具有统计学意义(P<0.05);T分期,N分期,壁外血管侵犯,神经侵犯及脉管癌栓不同组间APT SI、ADC值的差异均无统计学意义(P>0.05)。APT SI、ADC值鉴别直肠黏液腺癌与普通腺癌的ROC曲线下面积分别为0.936、0.982;APT SI鉴别低级别与高级别普通腺癌的ROC曲线下面积为0.728。结论:APT有助于评估直肠癌患者的组织病理类型及肿瘤分级。Objective:To explore the correlation of amide proton transfer(APT) quantitative parameter with histopathological type and clinical staging of rectal carcinoma.Methods:Ninety-four patients with pathologically confirmed rectal carcinoma were retrospectively evaluated.All patients underwent high-resolution conventional MRI,APT and DWI.Parameters including APT signal intensity(APT SI) and apparent diffusion coefficient(ADC) were measured and compared among different histopathologic types,grades,stages,and structure invasion statuses.Results:APT SI and ADC values were higher in rectal mucinous adenocarcinoma(MC) than those in rectal common adenocarcinoma(AC)(P<0.001).The APT SI of AC group was lower than that in high-grade tumors(P<0.05).There was no significant difference for APT SI or ADC among different T stages,N stages,extramural vascular invasion(EMVI),perineural and lymphovascular invasions(P>0.05).The area under the curves(AUCs) of APT SI and ADC values for distinguishing MC from AC were 0.936 and 0.982,respectively.The AUC of APT SI in distinguishing low-from high-grade AC were 0.728.Conclusion:APT was helpful to assess the histopathological type and grade of rectal carcinoma.

关 键 词：酰胺质子转移 直肠肿瘤 腺癌 磁共振成像 病理类型 分期 

分 类 号：R445.2[医药卫生—影像医学与核医学] R735.37[医药卫生—诊断学]