超声脐动脉血流S/D值联合血清β-HCG、FE_(3)、EPO对胎儿宫内窘迫的诊断价值  

Evaluation of Ultrasound Umbilical Artery Blood Flow S/D Value Combined with Serumβ-HCG,FE_(3),EPO on Fetal Distress

作　　者：徐月霞 张方方 权雅兵 XU Yuexia;ZHANG Fangfang;QUAN Yabing(Color Ultrasound Room,Luoyang Petrochemical Hospital,Luoyang 471000,China)

机构地区：[1]洛阳石化医院彩超室,河南洛阳471000

出　　处：《河南医学研究》2022年第20期3753-3756,共4页Henan Medical Research

摘　　要：目的探讨超声脐动脉血流收缩末期峰值(S)/舒张末期峰值(D)联合血清人绒毛膜促性腺激素(β-HCG)、游离雌三醇(FE_(3))、促红细胞生成素(EPO)对胎儿宫内窘迫(FD)的诊断价值。方法回顾性分析洛阳石化医院2018年7月至2020年7月收治的64例FD孕妇的临床资料,将其设置为观察组,另选取同期在医院行健康体检的60例孕妇作为对照组,所有孕妇均接受超声检查及血清β-HCG、FE_(3)、EPO检测,对比两组孕妇S/D值、血清β-HCG、FE_(3)、EPO水平差异;采用Pearson相关性分析S/D值、血清β-HCG、FE_(3)、EPO水平与FD的关系,通过接受者操作特征曲线(ROC曲线)分析S/D值、血清β-HCG、FE_(3)、EPO水平对FD的诊断价值。结果观察组孕妇S/D值、β-HCG、EPO水平均高于对照组,FE_(3)水平低于对照组(P<0.05)。Pearson相关性分析结果显示,FD与S/D值、β-HCG、EPO水平呈正相关,与FE_(3)水平呈负相关(P<0.05)。ROC曲线分析显示,S/D值、β-HCG、FE_(3)、EPO水平及4项指标联合诊断FD的AUC依次为0.766、0.902、0.832、0.785、0.998,敏感度依次为57.8%、82.8%、64.1%、50.0%、92.2%,特异度依次为90.0%、90.0%、90.0%、100.0%、100.0%,差异有统计学意义(P<0.05)。结论S/D值、β-HCG、EPO水平的上升,FE_(3)水平的下降与孕妇发生FD有关,联合各项指标对诊断孕妇FD具有较好的临床预测价值,值得临床参考借鉴。Objective To explore the evaluation of the peak end-systolic(S)/end-diastolic(D)peak of umbilical artery blood flow combined with serum human chorionic gonadotropin(β-HCG),free estriol(FE_(3)),erythropoietin(EPO)on fetal distress(FD).Methods The clinical data of 64 pregnant women with FD admitted to the Luoyang Petrochemical Hospital from July 2018 to July 2020 were retrospectively analyzed,and they were set as the observation group,and 60 pregnant women who underwent physical examination during the same period were selected as the control group.All pregnant women underwent ultrasound examination and serumβ-HCG,FE_(3)and EPO detection,and the differences in S/D value,serumβ-HCG,FE_(3)and EPO levels of the two groups of pregnant women were compared.The relationship between the levels of S/D value serumβ-HCG,FE_(3),EPO and FD were analyzed by Pearson correlation analysis,and the diagnostic value of S/D value,serumβ-HCG,FE_(3)and EPO levels for FD were analyzed through the receiver operating characteristic curve(ROC curve).Results The S/D value,β-HCG and EPO levels of pregnant women in the observation group were higher than those in the control group,and the FE_(3)level was lower than that in the control group.Pearson correlation analysis showed that FD were positively correlated with S/D value,β-HCG,EPO levels,and it was negatively correlated with FE_(3)levels(P<0.05).The ROC curve analysis showed that the AUC of S/D value,β-HCG,FE_(3),EPO level and the four indicators combined to diagnose FD were 0.766,0.902,0.832,0.785,0.998,and the sensitivity were 57.8%,82.8%,64.1%,50.0%,92.2%,the specificity were 90.0%,90.0%,90.0%,100.0%,100.0%,and the differences were statistically significant(P<0.05).Conclusion The increase of S/D value,β-HCG,EPO level,and the decrease of FE_(3)level are related to the occurrence of FD in pregnant women.The combination of various indicators has good clinical predictive value for the diagnosis of FD in pregnant women,which is worthy of clinical reference.

关 键 词：脐动脉血流收缩末期峰值/舒张末期峰值 人绒毛膜促性腺激素 游离雌三醇 促红细胞生成素 胎儿宫内窘迫 

分 类 号：R714.2[医药卫生—妇产科学]