MRI参数联合β-CTX、PAI-1对股骨头坏死及分期的诊断分析  

Analysis of MRI Parameters Combined withβ-CTX and PAI-1 in the Diagnosis and Staging of Femoral Head Necrosis

作　　者：丁娟[1] 李宇宏 赵宏春[1] 郭毅[1] 柳雨曦 曹文彬[1] DING Juan;LI Yuhong;ZHAO Hongchun;GUO Yi;LIU Yuxi;CAO Wenbin(Department of Radiology,Meishan Hospital of Traditional Chinese Medicine,Meishan 620010,Sichuan,P.R.China)

机构地区：[1]四川省眉山市中医医院放射科,四川眉山620010

出　　处：《影像科学与光化学》2022年第6期1407-1411,共5页Imaging Science and Photochemistry

摘　　要：本文分析磁共振成像(MRI)联合Ⅰ型胶原C端肽交联(β-CTX)、1型纤溶酶原激活物抑制剂(PAI-1)对股骨头坏死的诊断价值。选取112例疑似股骨头坏死的患者作为研究对象,以手术病理学检查诊断为“金标准”,将确诊为股骨头坏死的80例患者设为研究组,32例非股骨头坏死患者设为对照组。两组均行MRI检查,同时检查两组β-CTX、PAI-1水平。与对照组相比,研究组首次峰值(fEmax)、最大强化峰值(Emax)参数降低,达峰时间(TTP)参数升高(P<0.05)。股骨头坏死Ⅰ~Ⅳ期患者中,Ⅳ期患者fEmax、Emax、β-CTX水平最低,TTP参数、PAI-1水平最高(P<0.05)。fEmax、Emax、TTP、β-CTX、PAI-1与不同临床分期相关(P<0.05)。与fEmax(AUC=0.605)、Emax(AUC=0.594)、TTP(AUC=0.822)、β-CTX(AUC=0.617)、PAI-1(AUC=0.816)单项诊断相比,五项联合(AUC=0.831)对股骨头坏死诊断价值较高(P<0.05)。MRI联合β-CTX、PAI-1对股骨头坏死及分期具有较高的诊断价值。This paper analyzed the diagnostic value of magnetic resonance imaging(MRI)combined withβ-C-terminal cross-linking telopeptide of type 1 collagen(β-CTX)and plasminogen activator inhibitor-1(PAI-1)in the diagnosis of femoral head necrosis.A total of 112 patients with suspected femoral head necrosis were selected as the research objects.According to the operative pathological examination as the“gold standard”,80 cases diagnosed with femoral head necrosis were set as the research group,32 cases of non-femoral head necrosis were set as the control group.MRI examination was performed in both groups,and the levels ofβ-CTX and PAI-1 in both groups were also examined.Compared with the control group,the first maximum reinforcement peak(fEmax)and the maximum reinforcement peak(Emax)in the study group were decreased,and the parameters of time to peak(TTP)were increased(P<0.05).In patients with femoral head necrosis stageⅠ-Ⅳ,the patients with stageⅣnecrosis of the femoral head,the levels of fEmax,Emax andβ-CTX were the lowest,while the levels of TTP parameters and PAI-1 were the highest(P<0.05).fEmax,Emax,TTP,β-CTX and PAI-1 were correlated with different clinical stages(P<0.05).Compared with the single diagnosis of fEmax(AUC=0.605),Emax(AUC=0.594),TTP(AUC=0.822),β-CTX(AUC=0.617),and PAI-1(AUC=0.816),the five-item combination(AUC=0.831)had higher diagnostic value for femoral head necrosis(P<0.05).MRI combined withβ-CTX and PAI-1 has high diagnostic value in the diagnosis and staging of femoral head necrosis.

关 键 词：股骨头坏死 磁共振成像 Ⅰ型胶原C端肽交联 1型纤溶酶原激活物抑制剂 

分 类 号：R681.8[医药卫生—骨科学]