血管腔内药物球囊治疗下肢ASO的效果及对患肢超声参数的影响  

The Effect of Intravascular Drug Balloon in the Treatment of Lower Extremity ASO and Its Influence on the Ultrasound Parameters of the Affected Extremity

作　　者：杨彦林[1] 吴国良[1] 田少勇[1] 王春燕 赵鹏飞 YANG Yanlin;WU Guoliang;TIAN Shaoyong;WANG Chunyan;ZHAO Pengfei(Department of Interventional Radiology,Harrison International Peace Hospital,Hengshui 053000,Hebei,P.R.China;Department of Radiology,Hengshui Hospital of Traditional Chinese Medicine,Hengshui 053000,Hebei,P.R.China)

机构地区：[1]哈励逊国际和平医院介入科,河北衡水053000 [2]衡水市中医医院放射科,河北衡水053000

出　　处：《影像科学与光化学》2022年第6期1491-1496,共6页Imaging Science and Photochemistry

基　　金：2020年度河北省医学科学研究课题计划(20200407)。

摘　　要：本文研究目的是探讨下肢动脉硬化性闭塞症(ASO)血管腔内药物球囊治疗效果及对患肢超声参数的影响。选取120例下肢动脉硬化性闭塞症患者分为观察组(n=58)和对照组(n=62),观察组给予腔内药物球囊治疗,对照组给予普通球囊治疗,观察两组血清C反应蛋白(CRP)、白细胞介素16(IL-16)、健康调查简表(SF-36)评分等。观察组术后24 h时CRP、超敏C反应蛋白(hs-CRP)、IL-6和内皮素-1(ET-1)明显低于对照组(P<0.05),而一氧化氮(NO)明显高于对照组(P<0.05)。观察组术后12个月踝肱指数(ABI)、患肢超声参数、SF-36量表评分明显高于对照组(P<0.05),观察组血管再狭窄率和靶血管的晚期管腔丢失(LLL)明显低于对照组(P<0.05)。血管腔内药物球囊治疗下肢ASO有较好的效果,改善患者患肢功能及生活质量,减轻患者炎症反应。The aim of the study was to investigate the therapeutic effect of lower extremity arteriosclerotic occlusive disease(ASO)and its effect on the ultrasonographic parameters of the affected limb.A total of 120 lower limb ASO patients were divided into an observation group(n=58)and a control group(n=62).The observation group was treated with intracavitary drug balloon and the control group was treated with ordinary balloon,the levels of serum C-reactive protein(CRP),interleukin-16(IL-16)and SF-36 and so on were observed.At 24 hours after operation,CRP,High sensitivity C-reactive protein(hs-CRP),IL-6 and endothelin-1(ET-1)in the observation group were significantly lower than those in the control group(P<0.05),while nitric oxide(NO)was significantly higher than those in the control group(P<0.05).The scores of ankle brachial index(ABI),ultrasonic parameters of affected limband SF-36 in the observation group were significantly higher than those in the control group 12 months after operation(P<0.05).The restenosis rate and late lumen loss(LLL)of target vessels in the observation group were significantly lower than those in the control group(P<0.05).Endovascular drug balloon has a good effect in the treatment of lower extremity ASO,improves affected limb function and the quality of life,reduces the inflammatory reaction of patients.

关 键 词：下肢血管闭塞性病变 药物球囊 治疗效果 炎性因子 

分 类 号：R445.1[医药卫生—影像医学与核医学] R543.5[医药卫生—诊断学]