剖析益生菌与肥胖  

Analysis of Probiotics and Obesity

作　　者：赵爱青[1] 杨德兵[1] 常青[1] ZHAO Ai-qing;YANG De-bing;CHANG Qing(Medical School,Shanxi Datong University,Datong Shanxi,037009)

机构地区：[1]山西大同大学医学院,山西大同037009

出　　处：《山西大同大学学报（自然科学版）》2022年第5期49-52,共4页Journal of Shanxi Datong University(Natural Science Edition)

摘　　要：肥胖作为一种慢性代谢性疾病,引起的健康风险越来越受到人们的重视。过量的食物摄取、久坐的生活习惯、高糖和高脂的饮食习惯及遗传因素等均可以导致肥胖。随着消费者对健康和体型的关注度不断提高,减肥需求日益凸显。综述了肠道微生物与肥胖之间关系的最新进展,评估了肠道微生物影响宿主代谢的一些重要的分子机制如胆盐代谢、短链脂肪酸代谢和代谢性内毒素血症,并探索了益生菌调控肥胖的可能机理。此外,关于益生菌减重前景及存在的问题也有所涉及。As a chronic metabolic disease,obesity has attracted more and more attention due to its health risks.Excessive food consumption,sedentary way of life,high sugar consumption,fat-rich diet,and certain genetic profile may lead to obesity.As consumers pay more attention to health and body shape,the demand for weight loss has become increasingly prominent.This review summarizes the latest developments in the relationship between gut microbes and obesity,assesses important biological molecular mechanisms underlying the impact of gut microbiota on hosts including bile salt metabolism,short-chain fatty acids,and metabolic endotoxemia,and explores the possible mechanism of probiotics regulating obesity.In addition,the weight loss prospects and existing problems of probiotics are also discussed in the article.

关 键 词：肥胖 肠道微生物 益生菌 机制 

分 类 号：R589.2[医药卫生—内分泌] Q93[医药卫生—内科学]