Improving the prognosis before and after liver transplantation:Is muscle a game changer?  

作　　者：Alexis Goffaux Alicia Delorme Géraldine Dahlqvist Nicolas Lanthier 

机构地区：[1]Laboratory of Hepato-Gastroenterology,Institut de Recherche Expérimentale et Clinique,Universitécatholique de Louvain,Brussels 1200,Belgium [2]Service d’Hépato-Gastroentérologie,Cliniques universitaires Saint-Luc,Universitécatholique de Louvain,Brussels 1200,Belgium

出　　处：《World Journal of Gastroenterology》2022年第40期5807-5817,共11页世界胃肠病学杂志（英文版）

摘　　要：Liver transplantation(LT)is currently the only curative treatment option for selected patients with end stage liver disease or hepatocellular carcinoma.Improving waiting list-mortality,post-transplant morbidity and mortality and refining the selection of the patients remain our current central objectives.In this field,different concepts dealing with nutrition and the muscle such as sarcopenia,malnutrition,frailty or myosteatosis have emerged as possible game changers.For more than a decade,many prospective studies have demonstrated that sarcopenia and frailty are major predictive factors of mortality in the waiting list but also after LT.Malnutrition is also a well-known risk factor for morbidity and mortality.Muscle composition is a newer concept giving insight on muscle quality which has also been shown to be linked to poorer outcomes.Each of these terms has a precise definition as well as pathophysiological mechanisms.The bidirectional liver-muscle axis makes sense in this situation.Defining the best,easy to use in clinical practice tools to assess muscle quality,quantity,and function in this specific population and developing quality prospective studies to identify interventional strategies that could improve these parameters as well as evaluate the effect on mortality are among the important challenges of today.

关 键 词：MUSCLE Liver TRANSPLANTATION SARCOPENIA Myosteatosis FRAILTY 

分 类 号：R657.3[医药卫生—外科学]