姜黄改善神经退行性疾病的研究进展  

Research progress in Curcuma longa L. for the improvement of neurodegenerative diseases

作　　者：马诗经 余意 林晓亮 梁逸恒 杜志云 张婷 MA Shijing;YU Yi;LIN Xiaoliang;LIANG Yiheng;DU Zhiyun;ZHANG Ting(Guangzhou Conney Biotechnology Company Co.,Ltd.,Guangzhou 510006,China;Infinitus(China)Co.,Ltd.,Jiangmen 529156,China;School of Biomedical and Pharmaceutical Sciences,Guangdong University of Technology,Guangzhou 510006,China)

机构地区：[1]广州市康伦生物技术有限公司,广州510000 [2]无限极(中国)有限公司,江门529156 [3]广东工业大学生物医药学院,广州510006

出　　处：《上海医药》2022年第21期81-85,共5页Shanghai Medical & Pharmaceutical Journal

基　　金：国家自然科学基金面上项目(22178070);科技兴蒙项目(2021CG0029)。

摘　　要：随着全球老龄化趋势加剧,神经退行性疾病发病率不断升高,且由于其发病机制不明确,缺少有效的治疗药物,严重增加社会、家庭的经济压力及医疗负担。研究证实姜黄对神经退行性疾病有显著疗效,其主要通过抑制淀粉样蛋白沉积、抗氧化、神经保护、抗炎作用,在阿尔茨海默病、帕金森病、癫痫等神经退行性疾病的治疗中起着重要作用。本文综述了姜黄活性成分在神经退行性疾病的治疗作用及机制,为开发改善神经退行性疾病的姜黄药物及功能食品提供参考。The incidence of neurodegenerative diseases continues to increase with the global aging trend intensifies,which will seriously increase the economic pressure and medical burden on society and families due to the unclear pathogenesis and the lack of effective therapeutic drugs. A large number of studies have confirmed that turmeric(Curcuma longa L.) has a good effect on improving the symptoms of neurodegenerative diseases and it mainly plays an important role in neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease and epilepsy by inhibiting amyloid deposition, antioxidant,neuroprotective and anti-inflammatory effects. This article reviews the therapeutic effects and mechanisms of active turmeric ingredients in neurodegenerative diseases and provides reference for the development of turmeric drugs and functional foods for improving neurodegenerative diseases.

关 键 词：姜黄 姜黄素 姜黄挥发油 神经退行性疾病 

分 类 号：R282.71[医药卫生—中药学] R285[医药卫生—中医学]