Epigenetics in the etiology and management of infertility  

作　　者：Tajudeen Olanrewaju Yahaya Danlami M Bashar Esther O Oladele Ja'afar Umar Daniel Anyebe Abdulrazaq Izuafa 

机构地区：[1]Department of Biological Sciences,Federal University Birnin Kebbi,Kebbi State 23401,Nigeria [2]Department of Microbiology,Federal University Birnin Kebbi,Kebbi State 23401,Nigeria [3]Biology Unit,Distance Learning Institute,University of Lagos,Lagos State 23401,Nigeria [4]Department of Biochemistry and Molecular Biology,Federal University Birnin Kebbi,Kebbi State 23401,Nigeria

出　　处：《World Journal of Medical Genetics》2022年第2期7-21,共15页世界医学遗传学杂志

摘　　要：BACKGROUND Epigenetic disruptions have been implicated in some cases of infertility and can serve as therapeutic targets.However,the involvement of epigenetics in infertility has not received adequate attention.AIM This study aimed to determine the epigenetic basis of infertility in order to enhance public knowledge.METHODS Relevant articles on the subject were collected from PubMed,RCA,Google Scholar,SpringerLink,and Scopus.The articles were pooled together and duplicates were removed using Endnote software.RESULTS Available information shows that epigenetic mechanisms,mainly DNA methylation,histone modification,and microRNA interference are necessary for normal gametogenesis and embryogenesis.As a result,epigenetic disruptions in genes that control gametogenesis and embryogenesis,such as DDX3X,ADH4,AZF,PLAG1,D1RAS3,CYGB,MEST,JMJD1A,KCNQ1,IGF2,H19,and MTHFR may result in infertility.Aberrant DNA methylation during genomic imprinting and parental epigenetic mark erasures,in particular,may affect the DNA epigenomes of sperm and oocytes,resulting in reproductive abnormalities.in the sperm may also cause reproductive abnormalities.Furthermore,overexpression or repression of certain microRNAs embedded in the ovary,testis,embryo,as well as granulosa cells and oocytes may impair reproduction.Male infertility is characterized by spermatogenesis failure,which includes oligozoospermia,asthenozoospermia,and teratozoospermia,while female infertility is characterized by polycystic ovary syndrome.Some epigenetic modifications can be reversed by deactivating the regulatory enzymes,implying that epigenetic reprogramming could help treat infertility in some cases.For some disorders,epigenetic drugs are available,but none have been formulated for infertility.CONCLUSION Some cases of infertility have an epigenetic etiology and can be treated by reversing the same epigenetic mechanism that caused it.As a result,medical practitioners are urged to come up with epigenetic treatments for infertility that have an epigenetic cause.

关 键 词：DNA methylation GAMETOGENESIS INFERTILITY Polycystic ovary syndrome OLIGOZOOSPERMIA TERATOZOOSPERMIA 

分 类 号：R73[医药卫生—肿瘤]