丹参酮提取物的急性毒性及抗炎试验研究  

Study on Acute Toxicity and Anti Inflammation of Tanshinone Extract

作　　者：陶蕾 王广宇 王明彦 陈彦亮 樊志强 TAO Lei;WANG Guangyu;WANG Mingyan;CHEN Yanliang;FAN Zhiqiang(Lanzhou Vocational and Technical College,Lanzhou 730070,China;Sanmenxia Guangyu Biological Pharmaceutical Co.,Ltd.,San Menxia,472400,China;Henan Traditional Chinese Medicine Production Technology Promotion Center,Zhengzhou 450000,China)

机构地区：[1]兰州市职业技术学院,甘肃兰州730070 [2]三门峡广宇生物制药有限公司,河南三门峡472400 [3]河南省中药材生产技术推广中心,河南郑州450000

出　　处：《生物化工》2022年第5期90-92,102,共4页Biological Chemical Engineering

基　　金：三门峡市引进高层次人才(团队)创新创业项目(2020101);兰州市科技计划项目(2019-ZD-153);大学生创新创业训练计划项目(202112833002)。

摘　　要：目的:验证丹参酮提取物的急性毒性和抗炎效果,为临床安全用药提供依据。方法:本研究通过对昆明小鼠灌胃丹参酮提取物,分析丹参提取物所含毒性程度和实际抗炎成效。结果:小鼠服用丹参酮提取物后,未产生严重的负性反应和副作用,表明丹参酮提取物属于无毒物质。通过构建多种临床急性炎症模型,包括耳发炎肿胀模型、血管通透性增加以及足趾发炎肿胀,并以纸片肉芽肿炎症反应作为慢性炎症反应模型,分析丹参提取物的实际抗炎效果。发现丹参酮提取物对3种急性炎症模型均有一定的抑制作用,同时,其对慢性炎症反应亦有显著成效。结论:提示丹参酮提取物对急性以及慢性炎症反应皆有较好的抑制作用。Objective: To verify the acute toxicity and anti-inflammatory effect of tanshinone extract, and provide the basis for clinical safe drug use. Methods: This study analyzes the toxicity and actual anti-inflammatory effect of tanshinone extract by intragastric administration to Kunming mice. Results: There are no serious negative reactions and side effects in mice after taking the extract of Salvia miltiorrhiza Bge. It is a non-toxic substance. In this study,the actual anti-inflammatory effect of tanshinone is analyzed by constructing a variety of clinical acute inflammation models, including ear inflammation and swelling model, increased vascular permeability model and toe inflammation and swelling model, and taking the granulomatous inflammation of paper as a chronic inflammation model. The results show that tanshinone have certain resistance and inhibition to the three acute inflammation models, and have significant effect on chronic inflammation. Conclusion: Suggesting that the drug had good resistance to both acute and chronic inflammation.

关 键 词：丹参酮提取物 急性毒性反应 抗炎 炎症模型 

分 类 号：R284[医药卫生—中药学]