胰岛素抵抗和颅颈血管病变相关性  

The progress on the correlation between insulin resistance and intracranial and cervical vascular lesions

作　　者：孙景萍 徐晨悦 勾岚 纪孜硕 金奥铭 潘岳松[3] Sun Jingping;Xu Chenyue;Gou Lan;Ji Zishuo;Jin Aoming;Pan Yuesong(Department of Neurology,the Central Hospital of Lishui,Lishui Clinical Research Center for Neurological Diseases,Lishui 323000,China;不详)

机构地区：[1]丽水市中心医院神经内科,丽水市神经系统疾病临床研究中心,丽水323000 [2]首都医科大学 [3]首都医科大学附属北京天坛医院,国家神经系统疾病临床研究中心

出　　处：《中国临床保健杂志》2022年第5期614-618,共5页Chinese Journal of Clinical Healthcare

基　　金：国家自然科学基金项目(81971091);首都医科大学“本科生科研创新”项目(XSKY2021289)。

摘　　要：胰岛素抵抗是外周组织对胰岛素反应不足,逐渐导致糖耐量受损,进而发展为2型糖尿病的一种状态。越来越多的流行病学研究发现胰岛素抵抗与颅颈血管病变的发生、进展及预后有密切关系,但由于测量准确度、研究样本量、混杂因素等问题,尚未有明确的证据支持早期筛查胰岛素抵抗能够预防颅颈血管疾病,仍需要更准确的测量工具和分析策略来正确解释胰岛素抵抗与颅内和颈部血管病变之间的因果关系。该文围绕胰岛素抵抗的流行现况及与颅内和颈部血管病变的相关性方面综述胰岛素抵抗和颅颈血管病变的流行病学研究现状和进展。Insulin resistance is a state in which peripheral tissues do not respond adequately to insulin, gradually leading to impaired glucose tolerance and then to the development of type 2 diabetes.An increasing number of epidemiological studies have found that insulin resistance is closely related to the development and progression of intracranial and cervical vascular lesions.However, due to issues of measurement accuracy, study sample size, and confounding factors, there is not yet clear evidence to support that early screening for insulin resistance can prevent intracranial and cervical vascular disease.More accurate measurement tools and analytical strategies are still needed to properly interpret the causal relationship between insulin resistance and intracranial and cervical vascular lesions.This paper reviews the progress of research on the correlation between insulin resistance and intracranial and cervical vascular lesions, focusing on the epidemiology and measurement methods of insulin resistance, and its correlation with intracranial and cervical vascular lesions.

关 键 词：胰岛素抵抗 动脉粥样硬化 颅内栓塞和血栓形成 颈动脉血栓形成 

分 类 号：R587.2[医药卫生—内分泌] R743[医药卫生—内科学]