多囊卵巢综合征患者IGF-1、ADAMTS-1及sST2的表达及临床意义  

Expressions and clinical significance of IGF-1, ADAMTS-1 and sST2 in patients with polycystic ovary syndrome

作　　者：焦艳 王娇 杨志琴 冀雪霞 JIAO Yan;WANG Jiao;YANG Zhiqin;JI Xuexia(Department of Reproductive Medicine,Hengshui People's Hospital,Hengshui Hebei 053000,China)

机构地区：[1]衡水市人民医院生殖医学科,河北衡水053000

出　　处：《空军航空医学》2022年第5期248-251,共4页AVIATION MEDICINE OF AIR FORCE

基　　金：衡水市科技计划项目(2017014027Z)。

摘　　要：目的 分析多囊卵巢综合征(polycystic ovary syndrome,PCOS)患者类胰岛素样生长因子1(insulin like growth factor1,IGF-1)、Ⅰ型血小板结合蛋白基序的解聚蛋白样金属蛋白酶-1(adisintesrinandmetalloproteasewiththrombospond intype1motifs,ADAMTS-1)及可溶性ST2(sST2)的表达及临床意义。方法 选择2021年3月—2022年3月衡水市人民医院收治PCOS患者104例为观察组,另选取同期检查未孕健康妇女102人为对照组。对比不同人群、PCOS患者不同年龄段IGF-1、ADAMTS-1、sST2、性激素六项、总胆固醇、高密度脂蛋白、低密度脂蛋白、三酰甘油水平,分析IGF-1、ADAMTS-1、sST2与性激素六项水平相关性,IGF-1、ADAMTS-1、sST2诊断效能。结果 观察组IGF-1、sST2、黄体生成素、促卵泡生成素、睾酮、雌二醇水平均显著高于对照组,ADAMTS-1、孕酮及泌乳素水平均低于对照组(P<0.05);2组总胆固醇、高密度脂蛋白、低密度脂蛋白、三酰甘油比较差异无统计学意义(P>0.05)。各年龄段IGF-1、ADAMTS-1、sST2水平差异均有统计学意义(P<0.05)。IGF-1、sST2与黄体生成素、促卵泡生成素、睾酮及雌二醇呈正相关,与孕酮、泌乳素呈负相关;ADAMTS-1与孕酮、泌乳素呈正相关,与黄体生成素、促卵泡生成素、睾酮及雌二醇呈负相关,差异具有统计学意义(P<0.05)。IGF-1准确性为86.29%,ADAMTS-1准确性为92.37%,sST2准确性为89.05%。结论 IGF-1、ADAMTS-1、sST2可能参与PCOS疾病发生过程,其水平在其中呈异常表达,可以作为PCOS的诊断指标。Objective To analyze the expressions and clinical significance of insulin like growth factor 1(IGF-1),a disintesrin and metalloprotease with thrombospond in type 1 motifs(ADAMTS-1)and soluble ST2(sST2)in patients with polycystic ovary syndrome(PCOS). Methods One hundred and four patients with PCOS admitted to our hospital between March 2021 and March 2022 were selected as the observation group, while another 102 healthy women who were not pregnant during the same period were chosen as the control group. The levels of IGF-1, ADAMTS-1, sST2, sex hormones, total cholesterol, high density lipoprotein, low-density lipoprotein and triglyceride were compared between different populations and age groups of PCOS patients. The correlations between IGF-1, ADAMTS-1, sST2 and sex hormones were analyzed, and the diagnostic efficacy of IGF-1, ADAMTS-1 and sST2 was determined. Results The levels of IGF-1, sST2, luteinizing hormone, follicular estrogen, testosterone and estradiol in the observation group were significantly higher than those of the control group, but the levels of ADAMTS-1,progesterone and prolactin were lower(P<0.05). There was no difference in levels of total cholesterol, high-density lipoprotein, low-density lipoprotein or triglyceride between the two groups(P>0.05), but there was significant difference in the levels of IGF-1, ADAMTS-1and sST2 between age groups(P<0.05). IGF-1 and sST2 were positively correlated with luteinizing hormone, follicular estrogen, testosterone and estradiol, but negatively with progesterone and prolactin. ADAMTS-1 was positively correlated with progesterone and prolactin, but negatively with luteinizing hormone, follicular estrogen, testosterone and estradiol,and the difference was statistically significant(P<0.05). The accuracy was 86.29% for IGF-1,92.37% for ADAMTS-1and 89.05% for sST2. Conclusion IGF-1, ADAMTS-1, and sST2 may be involved in the pathogenesis of PCOS, the levels of which are abnormally expressed, which can be used as diagnostic indicators for PCOS.

关 键 词：多囊卵巢综合征 诊断 胰岛素样生长因子1 I型血小板结合蛋白基序的解聚蛋白样金属蛋白酶-1 

分 类 号：R711.75[医药卫生—妇产科学]