透明质酸敷料促进Picoway激光术后皮肤屏障的修复  

Hyaluronic acid medical dressing promotes skin barrier repair after Picoway laser treatment

作　　者：陈凤娟 柯锦 钱丽洁 马委委 王雄[1] CHEN Feng-juan;KE Jin;QIAN Li-jie;MA Wei-wei;WANG Xiong(Department of Dermatology,the Sixth People's Hospital Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200233;Department of Dermatology,Pudong Hospital Affiliated to Fudan University,Shanghai 201399,China)

机构地区：[1]上海交通大学医学院附属第六人民医院皮肤科,上海200233 [2]复旦大学附属浦东医院皮肤科,上海201399

出　　处：《基础医学与临床》2022年第12期1916-1920,共5页Basic and Clinical Medicine

基　　金：上海市卫健委中医药科研项目(2020LP006)。

摘　　要：目的研究透明质酸医用创面敷料在超皮秒(Picoway)激光术后对皮肤屏障修复的有效性和安全性。方法招募了30例面部接受激光术后的受试者,随机分为试验组和对照组。试验组治疗后即刻给予医用创面敷料和上海市皮肤病医院自制的单乳膏修护皮肤,对照组只给予单乳膏,连续使用7 d。结果皮肤图像分析仪(VISIA-6)定量检测结果显示,与对照组相比,激光治疗后7 d试验组的红色区、棕色斑和纹理明显改善(P<0.05);CK皮肤测试仪(MPA-580)检测结果显示,在激光治疗后不同时间点,试验组皮肤含水量明显高于对照组,各时间点经皮水分丢失明显低于对照组(P<0.05)。30例受试者未出现严重不良反应。结论透明质酸医用创面敷料能促进Picoway激光术后皮肤屏障修复。Objective To study the efficacy and safety of hyaluronic acid medical wound dressing on skin repair after Picoway laser treatment.Methods Thirty patients after Picoway laser treatment were randomly divided into medical wound dressing group and control group.Medical wound dressing group was treated with medical wound dressing combined with the Danrushuang made by Shanghai Dermatology Hospital immediately after treatment,while the control group was treated with the Danrushuang made by Shanghai Dermatology Hospital alone for 7 days.Results The quantitative evaluation results of skin image analyzer(VISIA-6)showed that the improvement of redness area,texture and brown spots in the medical wound dressing group was better than that in the control group(P<0.05)after 7 days treatment.CK skin tester(MPA-580)showed that the skin water content of the medical wound dressing group was obviously higher than that of the control group at different time points after laser treatment,and the transepidermal water loss at each time point was significantly lower than that of the control group(P<0.05).There was no significant adverse events recorded in all patients.Conclusions The use of hyaluronic acid medical wound dressing after Picoway laser treatment may promote the recovery of the skin barrier,alleviate acute inflammatory reaction and have an obvious moisturizing effect.

关 键 词：透明质酸 Picoway激光 皮肤屏障 

分 类 号：R751[医药卫生—皮肤病学与性病学]