胃内微生态在胃癌发生过程中作用的研究进展  

Research progress on the role of gastric microecology in gastric carcinogenesis

作　　者：纪若愚 曹馨元 张亦臻 王强[1] 吴晰[1] 杨莹韵[1] 杨爱明[1] JI Ruo-yu;CAO Xin-yuan;ZHANG Yi-zhen;WANG Qiang;WU Xi;YANG Ying-yun;YANG Ai-ming(Department of Gastroenterology,Peking Union Medical College Hospital,CAMS&PUMC,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院消化内科,北京100730

出　　处：《基础医学与临床》2022年第12期1960-1964,共5页Basic and Clinical Medicine

基　　金：北京协和医院青年科研基金(PUMCH201911356)。

摘　　要：胃内存在独特的微生态系统,其稳态的破坏与胃癌的发生密切相关。胃癌的发生伴随着胃黏膜菌群失调,表现为菌群多样性下降和菌群构成改变。菌群失调则进一步诱发胃内代谢环境的紊乱,驱动了有助于胃癌发生和发展的肿瘤微环境的形成。探究胃内微生态参与胃癌发生的作用机制有利于为胃癌的诊断和治疗提供新思路。Human stomach has a unique microbial ecosystem,and the disruption of its homeostasis is closely associated with the development of gastric cancer(GC).Gastric carcinogenesis is correlated with the dysbiosis of gastric mucosal microbiota,which is characterized by the decrease of biologigical diversity and alterations of the composition.The microbiota dysbiosis further induces metabolic disorders and triggers the formation of tumor microenvironment in the stomach which contributes to the development and progression of GC.Exploring the role of gastric micro-ecology in gastric carcinogenesis may provide new insights into the diagnosis and treatment for GC.

关 键 词：胃微生态 胃癌 菌群失调 

分 类 号：N19[自然科学总论]