美罗培南治疗新生儿大肠埃希菌败血症的疗效及对患儿血清PCT、CRP、IL-6水平的影响  

Effect of meropenem on neonatal Escherichia coli septicemia and its effect on children's serum PCT,CRP,and IL-6 levels

作　　者：蔡丽燕 黄斯铭 张桂花 CAI Li-yan;HUANG Si-ming;ZHANG Gui-hua(Department of Neonatology,Sanshui District People's Hospital of Foshan,Foshan 528100,Guangdong,CHINA)

机构地区：[1]佛山市三水区人民医院新生儿科,广东佛山528100

出　　处：《海南医学》2022年第21期2795-2798,共4页Hainan Medical Journal

摘　　要：目的观察美罗培南治疗新生儿大肠埃希菌败血症的疗效,探讨其对患儿血清降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)水平的影响。方法选择2016年1月至2021年6月佛山市三水区人民医院新生儿科收治的60例新生儿大肠埃希菌败血症患儿纳入研究,按照随机数表法分为观察组和对照组各30例。在常规治疗基础上,对照组患儿采用注射用头孢他啶治疗,观察组患儿给予注射用美罗培南治疗,两组患儿均持续治疗7 d。比较两组患儿治疗7 d后的临床疗效、症状改善时间(拒奶改善时间、黄疸消失时间、体温正常时间)、住院时间,以及治疗前和治疗7 d后的血清PCT、CRP、IL-6水平、免疫球蛋白(Ig)M、IgA的变化。结果观察组患儿的治疗总有效率为96.66%,明显高于对照组的73.33%,差异有统计学意义(P<0.05);治疗后,观察组患儿的拒奶改善时间、黄疸消失时间、体温正常时间及住院时间分别为(4.74±1.22)d、(6.13±1.28)d、(3.27±0.53)d、(6.78±1.49)d,明显短于对照组的(6.85±1.36)d、(9.40±1.59)d、(5.88±1.06)d、(10.32±1.20)d,差异均有统计学意义(P<0.05);治疗后,观察组患儿的血清PCT、CRP、IL-6水平分别为(0.74±0.16)μg/L、(6.18±1.32)mg/L、(11.52±2.71)mg/L,明显低于对照组的(1.30±0.20)μg/L、(7.63±1.51)mg/L、(17.93±2.40)mg/L,IgM、IgA水平分别为(1.36±0.15)g/L、(3.80±0.37)g/L,明显高于对照组的(1.21±0.13)g/L、(3.15±0.29)g/L,差异均有统计学意义(P<0.05)。结论美罗培南治疗新生儿大肠埃希菌败血症有助于降低患儿的血清PCT、CRP、IL-6水平,治疗效果明显,具有临床应用价值。Objective To observe the efficacy of meropenem in the treatment of neonatal Escherichia coli septicemia,and to investigate its effect on children's serum levels of procalcitonin(PCT),C-reactive protein(CRP),and interleukin-6(IL-6).Methods A total of 60 neonates with Escherichia coli septicemia admitted to the Department of Neonatology,Sanshui District People's Hospital of Foshan from January 2016 to June 2021 were selected for this study.They were divided into an observation group and a control group according to random number table method,with 30 patients in each group.On the basis of conventional treatment,the control group was treated with ceftazidime for injection,and the observation group was treated with meropenem for injection.The treatment lasted for 7 days in both groups.The clinical efficacy at 7 days after treatment,symptom improvement time(improvement time of milk rejection,time of jaundice disappearance,time of temperature returning to normal),and length of hospital stay were compared between the two groups.The changes of serum PCT,CRP,IL-6 levels,immunoglobulin(Ig)M and IgA levels before treatment and at 7 days after treatment were compared.Results After treatment,the total effective rate of treatment in the observation group was 96.66%,which was significantly higher than 73.33%of the control group(P<0.05);after treatment,the improvement time of milk rejection,time of jaundice disappearance,time of temperature returning to normal,and length of hospital stay in the observation group were(4.74±1.22)d,(6.13±1.28)d,(3.27±0.53)d,(6.78±1.49)d,which were significantly shorter than(6.85±1.36)d,(9.40±1.59)d,(5.88±1.06)d,(10.32±1.20)d in the control group(P<0.05);after treatment,the serum PCT,CRP,IL-6 levels in observation group were(0.74±0.16)μg/L,(6.18±1.32)mg/L,(11.52±2.71)mg/L,which were significantly lower than(1.30±0.20)μg/L,(7.63±1.51)mg/L,(17.93±2.40)mg/L in the control group(P<0.05);the IgM and IgA levels in the observation group were(1.36±0.15)g/L and(3.80±0.37)g/L,which were signi

关 键 词：新生儿 败血症 大肠埃希菌 美罗培南 降钙素原 C反应蛋白 白细胞介素-6 

分 类 号：R722.1[医药卫生—儿科]