太赫兹波光声效应诊断皮肤癌仿真分析(特邀)  

Simulation Analysis of Skin Cancer Diagnosis Using Terahertz-waves Photoacoustic Effect(Invited)

作　　者：韩智超 韩一平[1] HAN Zhichao;HAN Yiping(School of Physics,Xidian University,Xi′an 710071,China)

机构地区：[1]西安电子科技大学物理学院,西安710071

出　　处：《光子学报》2022年第10期421-430,共10页Acta Photonica Sinica

基　　金：国家重点研究发展计划。

摘　　要：随着太赫兹源的发展,利用组织的太赫兹波光声效应以非入侵方式对病变组织进行区分检测展现了巨大优势。通过有限元方法仿真分析了在1.0 THz下皮肤及皮肤癌的热效应与光声效应,并通过光声信号对不同生长时期的基底细胞癌进行分析。仿真结果表明,可以通过光声信号有效区分不同皮肤结构与不同基底细胞癌生长时期。该结果揭示了利用太赫兹波光声效应实现早期皮肤癌的太赫兹无损诊断的应用价值。In recent years,Terahertz-waves have brought a brand-new,label-free,non-invasive detection method to biomedical research due to their non-ionization,broadband,and high signal-to-noise ratio.With the development of Terahertz sources,especially the generation of Terahertz pulses with energy up to mJ,the study of biological tissues in Terahertz band is no longer limited to non-thermal effects.Histopathological test is considered as the gold standard for diagnosing skin cancer and other tumors.However,the borders of some tumors are blurred,which may result in excessive surgery,mistaken resection,or inability to fully resection in the process of histopathological test.It is of great value to combine the physical properties of skin tissue and Basal Cell Carcinoma(BCC)with their optical properties in the Terahertz band for the non-destructive diagnosis of skin cancer.The purpose of this paper is to provide a certain theoretical basis for the non-destructive detection of early skin cancer by studying the photoacoustic effect of Terahertz-Waves in in vivo tissues(normal skin tissue,skin tissue containing basal cell carcinoma).In this paper,according to the dendritic growth law of basal cell carcinoma in the basal layer of skin tissue,combined with the absorption characteristics of skin tissue in the Terahertz band and the difference in water content between skin tissues,a skin tissue model containing basal cell carcinoma is established.The model includes the stratum corneum,epidermis,and lesions of different basal cell carcinomas.As a control,a structural model of normal skin tissue is also established.Using the Pennes heat transfer equation,the Terahertz radiative heat effects of normal skin tissue models and skin tissue models containing basal cell carcinoma are analyzed.Finally,the differences and components of photoacoustic signals between normal skin tissue models and skin tissue models containing different basal cell carcinoma growth stages are analyzed using the photoacoustic effect of Terahertz-Waves.The simulatio

关 键 词：太赫兹波 光声效应 光声信号 皮肤组织 基底细胞癌 

分 类 号：O441.4[理学—电磁学]