三黄膏贴敷疗法对阿扎胞苷注射所致皮肤不良反应的疗效分析  

Efficacy analysis of San-huang paste therapy on skin adverse reactions caused by azacitidine injection

作　　者：殷钰 孙彩虹[1] 袁菲[1] 代骞媛 许媚[1] Yin Yu;Sun Caihong;Yuan Fei;Dai Qianyuan;Xu Mei(Hematology Department,the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,Zhejiang,China)

机构地区：[1]浙江大学医学院附属第一医院血液科,浙江杭州310003

出　　处：《加速康复外科杂志》2022年第3期101-106,共6页JOURNAL OF ENHANCED RECOVERY AFTER SURGERY

基　　金：浙江省卫生健康科技计划临床研究应用项目(2022KY152)。

摘　　要：目的:探讨三黄膏贴敷疗法对阿扎胞苷皮下注射所致局部皮肤不良反应的疗效。方法:采用单中心单盲随机对照研究方法,连续纳入2021年7月至2022年3月浙江大学医学院附属第一医院血液科80例恶性血液病住院患者,按照随机数字表法分为三黄膏贴敷组和莫匹罗星组,每组各40例。莫匹罗星组患者在阿扎胞苷皮下注射处使用莫匹罗星软膏涂抹,三黄膏贴敷组患者使用三黄膏贴敷疗法,干预时长均为连续7 d。使用数字分级评分法(numerical pain rating scale,NRS)比较两组患者的疼痛程度,并根据中医证候疗效评价标准比较两组患者局部皮肤不良反应的疗效。结果:三黄膏贴敷组患者干预后注射部位局部皮肤不良反应的总有效率(92.5%)高于莫匹罗星组患者(70%),差异有统计学意义(P<0.05)。通过重复测量分析发现,两组间患者疼痛评分的组别与时间因素有交互作用(F=10.863,P<0.05),在治疗第8天三黄膏贴敷组患者注射部位疼痛评分显著低于莫匹罗星组患者,差异有统计学意义(P<0.05)。结论:三黄膏贴敷疗法、莫匹罗星软膏的早期应用对阿扎胞苷注射所致皮肤不良反应均有一定缓解作用,但三黄膏贴敷疗法具有止痛、散结、消肿且疗效更持久的优势,有助于加速患者康复过程。Objective:To investigate the effect of San-huang ointment application on local skin adverse reactions caused by subcutaneous injection of azacitidine.Method:Using a single-center and single-blind randomized controlled study method,80 inpatients with malignant hematological diseases were enrolled in the Hematology Department,the First Affiliated Hospital,Zhejiang University School of Medicine from July 2021 to March 2022.According to the random number table method,80 patients were randomly divided into San-huang ointment group and mupirocin group,with 40 patients in each group.The patients in the mupirocin group were smeared with mupirocin ointment at the subcutaneous injection site of azacitidine,and the patients in the San-huang ointment application group were applied with the Sanhuang ointment therapy,and the intervention time was 7 consecutive days.The pain degree of the two groups of patients was compared using the numerical pain rating scale(NRS),and the efficacy of local skin adverse reactions was compared between the two groups according to the evaluation criteria of traditional Chinese medicine syndromes.Result:The total effective rate of local skin adverse reactions at the injection site in the San-huang ointment application group(92.5%)was higher than that in the mupirocin group(70%),and the difference was statistically significant(P<0.05).Through repeated measures analysis,it was found that there was an interaction between the pain scores of the two groups and the time factor(F=10.863,P<0.05).In the mupirocin group,the difference was statistically significant(P<0.05).Conclusion:The early application of San-huang ointment and mupirocin ointment has a certain alleviation effect on skin adverse reactions caused by azacitidine injection.However,the San-huang ointment sticking therapy has the advantages of relieving pain,dispersing knots,reducing swelling and having a more lasting effect,which helps to accelerate the recovery process of patients,and is worthy of popularization and application.

关 键 词：阿扎胞苷 三黄膏 红肿 硬结 疼痛 

分 类 号：R473.6[医药卫生—护理学]