Current developments of bioanalytical sample preparation techniques in pharmaceuticals  

作　　者：Rahul G.Ingle Su Zeng Huidi Jiang Wei-Jie Fang 

机构地区：[1]Institute of Drug Metabolism and Pharmaceutical Analysis,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou,310058,China [2]Hangzhou Institute of Innovative Medicine,Zhejiang University,Hangzhou,310016,China

出　　处：《Journal of Pharmaceutical Analysis》2022年第4期517-529,共13页药物分析学报（英文版）

基　　金：the National Natural Science Foundation of China(Grant No.:81741144);Ministry of Science and Technology of the People's Republic of China(Grant No.:2018ZX09J18107-002)for their financial assistance.

摘　　要：Sample preparation is considered as the bottleneck step in bioanalysis because each biological matrix has its own unique challenges and complexity.Competent sample preparation to extract the desired analytes and remove redundant components is a crucial step in each bioanalytical approach.The matrix effect is a key hurdle in bioanalytical sample preparation,which has gained extensive consideration.Novel sample preparation techniques have advantages over classical techniques in terms of accuracy,automation,ease of sample preparation,storage,and shipment and have become increasingly popular over the past decade.Our objective is to provide a broad outline of current developments in various bioanalytical sample preparation techniques in chromatographic and spectroscopic examinations.In addition,how these techniques have gained considerable attention over the past decade in bioanalytical research is mentioned with preferred examples.Modern trends in bioanalytical sample preparation techniques,including sorbent-based microextraction techniques,are primarily emphasized.

关 键 词：BIOANALYSIS Biological matrices Matrix effect MICROEXTRACTION Sample preparationtechnique 

分 类 号：R96[医药卫生—药理学]