Preparation of Fe_(3)O_(4)@SW-MIL-101-NH_(2) for selective preconcentration of chlorogenic acid metabolites in rat plasma,urine,and feces samples  

作　　者：Shi-Jun Yin Xi Zhou Li-Jing Peng Fang Li Guo-Can Zheng Feng-Qing Yang Yuan-Jia Hu 

机构地区：[1]Department of Pharmaceutical Engineering,School of Chemistry and Chemical Engineering,Chongqing University,Chongqing,401331,China [2]Analytical and Testing Center,Chongqing University,Chongqing,401331,China [3]State Key Laboratory of Quality Research in Chinese Medicine,Institute of Chinese Medical Sciences,University of Macao,Macao,999078,China

出　　处：《Journal of Pharmaceutical Analysis》2022年第4期617-626,共10页药物分析学报（英文版）

基　　金：sponsored by the Natural Science Foundation of Chongqing,China(Grant No.:cstc2019jcyj-msxmX0074);supported by the University of Macao(Grant No.:MYRG2019-00011-ICMS).

摘　　要：An innovative sandwich-structural Fe-based metal-organic framework magnetic material(Fe_(3)O_(4)@SWMIL-101-NH_(2))was fabricated using a facile solvothermal method.The characteristic properties of the material were investigated by field emission scanning electron microscopy,transmission electron microscopy(TEM),energy-dispersive X-ray spectroscopy,Fourier transform infrared spectroscopy,X-ray powder diffraction,vibrating sample magnetometry,and Brunauer-Emmett-Teller measurements.Fe_(3)O_(4)@SW-MIL-101-NH_(2) is associated with advantages,such as robust magnetic properties,high specific surface area,and satisfactory storage stability,as well as good selective recognition ability for chlorogenic acid(CA)and its metabolites via chelation,hydrogen bonding,and p-interaction.The results of the static adsorption experiment indicated that Fe_(3)O_(4)@SW-MIL-101-NH_(2) possessed a high adsorption capacity toward CA and its isomers,cryptochlorogenic acid(CCA)and neochlorogenic acid(NCA),and the adsorption behaviors were fitted using the Langmuir adsorption isotherm model.Then,a strategy using magnetic solid-phase extraction(MSPE)and ultra-performance liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry(UPLC-Q-TOF MS/MS)was developed and successfully employed for the selective pre-concentration and rapid identification of CA metabolites in rat plasma,urine,and feces samples.This work presents a prospective strategy for the synthesis of magnetic adsorbents and the high-efficiency pretreatment of CA metabolites.

关 键 词：Sandwich structure Metal-organic framework Chlorogenic acid Magnetic solid-phase extraction Metabolic pathway 

分 类 号：R285[医药卫生—中药学]