白细胞介素18的生理作用及其与妇科生殖疾病的相关性研究进展  

Physiological role of interleukin-18 and its correlation with gynecological reproductive diseases:research progress

作　　者：丁杰[1] 梅珊珊 程雯[1] 俞超芹[1] DING Jie;MEI Shan-shan;CHENG Wen;YU Chao-qin(Department of Traditional Chinese Medicine(Gynecology),The First Affiliated Hospital of Naval Medical University(Second Military Medical University),Shanghai 200433,China)

机构地区：[1]海军军医大学(第二军医大学)第一附属医院中医妇科,上海200433

出　　处：《海军军医大学学报》2022年第10期1181-1188,共8页Academic Journal of Naval Medical University

基　　金：国家自然科学基金(81774352,81573755,81703874,81603646,81503604);上海市妇幼健康中医专项建设项目;上海市科学技术委员会中医引导项目(19401930200).

摘　　要：IL-18属于IL-1家族,是一种多效性免疫调节因子。IL-18通过诱导γ干扰素发挥强烈的促炎作用,并与多种生殖相关妇科疾病存在关联。本文综述了IL-18的生理作用及其与妇科生殖疾病的相关性,从子宫内膜容受性、卵泡发育、生殖免疫等方面探讨IL-18对女性生殖生理的影响。Interleukin(IL)-18,an IL-1 family cytokine,is a pleiotropic immune regulator.IL-18 plays a strong proinflammatory role by inducing interferonγand is associated with diverse reproductive related gynecological diseases.This article reviews the physiological role of IL-18 and its correlation with gynecological reproductive diseases,and discusses the impacts of IL-18 on female reproductive physiology from the perspective of endometrial receptivity,folliclar development,and reproductive immunity.

关 键 词：白细胞介素18 子宫内膜异位症 多囊卵巢综合征 反复自然流产 子宫内膜容受性 卵泡发育 生殖免疫 

分 类 号：R711[医药卫生—妇产科学]