妊娠期糖尿病产妇临产时糖化白蛋白与新生儿低血糖症的相关性研究  

Correlation Between Glycated Albumin at Delivery and Neonatal Hypoglycemia in Pregnant Women with Gestational Diabetes Mellitus

作　　者：聂德方 张艳杰 张晓婷 Nie DeFang;Zhang Yanjie;Zhang Xiaoting(Department of Pediatrics,Foshan Second People's Hospital,Foshan 528000,China;Department of Internal Medicine,Foshan Maternal and Child Health Hospital,Foshan 528000,China)

机构地区：[1]佛山市第二人民医院儿科,广东佛山528000 [2]佛山市妇幼保健院内科,广东佛山528000

出　　处：《实用妇科内分泌电子杂志》2022年第13期1-3,共3页Electronic Journal of Practical Gynecological Endocrinology

基　　金：佛山市卫生健康局医学科研课题项目(编号20210028)。

摘　　要：目的探究妊娠期糖尿病产妇临产时糖化白蛋白与新生儿低血糖症的相关性。方法选取40例合并妊娠期糖尿病产妇及所产新生儿作为研究对象,将出现低血糖症的20例新生儿纳入A组,将未出现低血糖症的20例新生儿纳入B组。使用血糖仪对两组产妇血糖指标进行检测。比较两组产妇血糖指标、新生儿血糖水平及新生儿低血糖发生率。结果A组产妇糖化白蛋白水平高于B组,差异有统计学意义(P<0.05)。A组新生儿即时血糖水平低于B组,差异有统计学意义(P<0.05)。B组巨大儿发生率(5.00%)、剖宫产率(45.00%)低于A组(30.00%、75.00%),差异有统计学意义(P<0.05)。妊娠期糖尿病产妇糖化白蛋白水平与新生儿出生后1 h血糖水平呈负相关(P<0.05)。结论妊娠期糖尿病产妇的糖化白蛋白水平直接关系到新生儿的梢血糖指标,是影响妊娠结局的主要因素。临床及时及科学监测产妇糖化白蛋白水平,并尽早进行干预,以防止产妇血糖紊乱而对新生儿产生不利影响。Objective To explore the correlation between glycated albumin at delivery and neonatal hypoglycemia in pregnant women with gestational diabetes mellitus.Methods 40 pregnant women with gestational diabetes mellitus(GDM)and their neonates were selected as the research objects.20 neonates with hypoglycemia were included in group A,and 20 neonates without hypoglycemia were included in group B.Blood glucose meter was used to detect the blood glucose index of two groups of puerpera.Maternal blood glucose index,neonatal blood glucose level and incidence of neonatal hypoglycemia were compared between the two groups.Results The glycated albumin level in group A was higher than that in group B,and the difference was statistically significant(P<0.05).The immediate blood glucose level in group A was lower than that in group B,and the difference was statistically significant(P<0.05).The incidence of macrosomia(5.00%)and cesarean section(45.00%)in group B were lower than those in group A(30.00%,75.00%),and the differences were statistically significant(P<0.05).The glycated albumin level of gestational diabetes was negatively correlated with the blood glucose level of neonates 1 h after birth(P<0.05).Conclusion The level of glycated albumin in pregnant women with gestational diabetes mellitus is directly related to the level of blood glucose in umbilical cord blood of newborns,which is the main factor affecting the outcome of pregnancy.Clinical and scientific monitoring of maternal glycated albumin level,and early intervention to prevent maternal blood glucose disorder and adverse effects on the newborn.

关 键 词：妊娠期糖尿病 糖化白蛋白 新生儿 低血糖症 临产 

分 类 号：R714.256[医药卫生—妇产科学] R722.1[医药卫生—临床医学]