慢性HBV感染患者血清转氨酶、HBV-DNA载量与乙肝五项指标的临床价值分析  

Clinical value analysis of serum transaminase,HBV-DNA load and five indicators of hepatitis B in patients with chronic HBV infection

作　　者：楼韵燕 李晓飞[2] LOU Yunyan;LI Xiaofei(Department of Laboratory,Yiwu Central Hospital,Zhejiang,Yiwu 322000,China;Department of Infection,Yiwu Central Hospital,Zhejiang,Yiwu 322000,China)

机构地区：[1]义乌市中心医院检验科,浙江义乌322000 [2]义乌市中心医院感染科,浙江义乌322000

出　　处：《中国现代医生》2022年第31期44-47,共4页China Modern Doctor

基　　金：2021年义乌市科研计划项目(21-3-63)。

摘　　要：目的探讨慢性乙型肝炎病毒(hepatitis B virus,HBV)感染患者血清转氨酶、HBV-DNA载量与乙肝五项指标检测水平的临床价值。方法选取2020年1月至2022年1月义乌市中心医院收治的慢性乙型肝炎患者432例为研究对象,回顾性分析谷丙转氨酶(alanine aminotransferase,ALT)、谷草转氨酶(aspartate aminotransferase,AST)、γ-谷氨酰基转移酶(γ-glutamyltransferase,GGT)、HBV-DNA载量及乙肝五项指标水平。结果肝硬化患者的血清ALT水平及乙型肝炎表面抗原(hepatitis B surface antigen,HBsAg)阳性率均显著低于无肝硬化患者(P<0.05),HBV-DNA载量<30IU/ml的占比、血清AST、AST/ALT及GGT水平均显著高于无肝硬化患者(P<0.05),二者的乙型肝炎e抗原(hepatitis B e antigen,HBeAg)阳性率比较差异无统计学意义(P>0.05)。HBsAg(+)与HBsAg(-)患者比较,血清中ALT、AST、GGT水平差异均无统计学意义(P>0.05),HBsAg(+)患者的AST/ALT、HBV-DNA载量<30IU/ml的占比均显著低于HBsAg(-)患者(P<0.05)。不同HBV-DNA载量患者的血清ALT、AST、AST/ALT及GGT水平比较差异均有统计学意义(P<0.05),且随着HBV-DNA载量的增加,ALT、AST、GGT水平逐渐升高,AST/ALT逐渐降低。不同HBV-DNA载量患者的HBeAg阳性率比较,差异无统计学意义(P>0.05)。结论慢性HBV感染患者的血清转氨酶、HBV-DNA载量与乙肝五项指标对判断慢性乙型肝炎肝硬化有一定应用价值。Objective To investigate the clinical value of serum transaminase,HBV-DNA load and five hepatitis B indicators in patients with chronic hepatitis B virus(HBV)infection.Methods A total of 432 patients with chronic hepatitis B admitted to Yiwu Central Hospital from January 2020 to January 2022 were selected as the research objects.the research objects.The levels of alanine aminotransferase(ALT),aspartate aminotransferase(AST),γ-glutamyltransferase(GGT),HBV-DNA load and hepatitis B five indexes in hepatitis B patients were retrospectively analyzed.Results The serum ALT level and hepatitis B surface antigen(HBsAg)positive rate of patients with cirrhosis were significantly lower than those without cirrhosis(P<0.05),the proportion of HBV-DNA load<30 IU/ml,serum AST,AST/ALT and GGT levels were significantly higher than those in patients without cirrhosis(P<0.05),and there was no significant difference in the positive rate of hepatitis B e antigen(HBeAg)between the two groups(P>0.05).There was no significant difference in serum ALT,AST and GGT levels between HBsAg(+)and HBsAg(-)patients(P>0.05),AST/ALT and the proportion of HBV-DNA load<30 IU/ml in HBsAg(+)patients was significantly lower than that in HBsAg(-)patients(P<0.05).There were significant differences in serum ALT,AST,AST/ALT and GGT levels among patients with different HBV-DNA load(P<0.05),and with the increase of HBV-DNA load,the levels of ALT,AST and GGT gradually increased,and the AST/ALT gradually decreased.There was no significant difference in the positive rate of HBeAg among patients with different HBV-DNA load(P>0.05).Conclusion The serum transaminase,HBV-DNA load and five indexes of hepatitis B in patients with chronic HBV infection have certain application value in judging chronic hepatitis B cirrhosis.

关 键 词：血清转氨酶 HBV-DNA载量 乙肝五项 乙型肝炎 肝硬化 

分 类 号：R512.6[医药卫生—内科学]