芩连温胆汤对痰热扰心型失眠的临床疗效观察  

Clinical observation of Qinlian Wendan Tang in the treatment of phlegm-heat disturbing heart type insomnia

作　　者：叶发 胡霖霖 张蕾 张金霞 YE Fa;HU Linlin;ZHANG Lei;ZHANG Jinxia(Sleep Medical Center,Hangzhou Dingqiao Hospital,Hangzhou 310021,China;Sleep Medical Center,Hangzhou Hospital of Traditional Chinese Medicine,Hangzhou 310007,China)

机构地区：[1]杭州市丁桥医院睡眠医学中心,浙江杭州310021 [2]杭州市中医院睡眠医学中心,浙江杭州310007

出　　处：《中国现代医生》2022年第31期95-98,103,共5页China Modern Doctor

基　　金：浙江省中医药科技计划项目(2021ZB190)。

摘　　要：目的观察芩连温胆汤治疗痰热扰心型失眠的临床疗效。方法选取2020年10月至2022年2月就诊于杭州市中医院的66例失眠患者为研究对象,根据随机数字表法将其分为对照组(n=31)和治疗组(n=35)。对照组患者予艾司唑仑片治疗,治疗组患者予芩连温胆汤治疗。比较两组患者治疗前后的中医证候积分、匹兹堡睡眠质量指数(Pittsburgh sleep quality index,PSQI)、多导睡眠图(polysomnography,PSG)参数及临床疗效。结果治疗后,两组患者的中医证候积分、PSQI评分均显著低于本组治疗前(P<0.05);治疗组患者的中医证候积分显著低于对照组(P<0.01)。治疗后,对照组患者的主观睡眠质量评分、睡眠潜伏期评分均显著低于治疗前(P<0.05);治疗组患者的睡眠持续性、习惯性睡眠效率、白天功能紊乱评分均显著低于治疗前(P<0.05)。治疗后,两组患者的实际总睡眠时间显著延长、睡眠效率提高(P<0.01);对照组患者的N2期时间显著延长(P<0.01),治疗组患者的N1期、N2期与快速眼动睡眠时间显著延长(P<0.05)。两组患者的治疗总有效率比较差异无统计学意义(P>0.05)。结论芩连温胆汤与艾司唑仑片对痰热扰心型失眠均有一定疗效,但芩连温胆汤对改善失眠中医证候积分、睡眠持续性、习惯性睡眠效率及白天功能紊乱的效果更显著,并可延长N1、N2及快速眼动睡眠时间。Objective To observe the clinical effect of Qinlian Wendan Tang o in the treatment of phlegm-heat disturbing heart type insomnia.Methods From October 2020 to February 2022,66 patients with insomnia in Hangzhou Hospital of Traditional Chinese Medicine were selected as the research objects.According to the random number table method,they were divided into control group(31 cases)and treatment group(35 cases).Patients in control group were treated with estazolam tablets,patients in treatment group were treated with Qinlian Wendan Tang.TCM syndrome integral,Pittsburgh sleep quality index(PSQI),and polysomnography(PSG)parameters and clinical curative effect were compared between two groups of patients before and after treatment.Results After treatment,the TCM syndrome scores and PSQI scores of the two groups were significantly lower than those before treatment(P<0.05).The TCM syndrome score of treatment group was significantly lower than that of control group(P<0.01).After treatment,the subjective sleep quality score and sleep latency score of control group were significantly lower than those before treatment(P<0.05),and the sleep persistence,habitual sleep efficiency and daytime dysfunction scores of treatment group were significantly lower than those before treatment(P<0.05).After treatment,the actual total sleep time of the two groups was significantly prolonged and sleep efficiency was improved(P<0.01).The duration of N2 stage in control group was significantly prolonged(P<0.01),while the duration of N1 stage,N2 stage and rapid eye movement(REM)sleep in treatment group was significantly prolonged(P<0.05).There was no significant difference in the total effective rate between the two groups(P>0.05).Conclusion Both Qinlian Wendan Tang and estazolam tablets have certain therapeutic effects on phlegm-heat disturbing heart type insomnia,but Qinlian Wendan Tang has more significant effects on improving TCM syndrome score,sleep persistence,habitual sleep efficiency and daytime dysfunction,and can prolong N1,N2 and REM sle

关 键 词：芩连温胆汤 痰热扰心 失眠 

分 类 号：R256.23[医药卫生—中医内科学]