抗核糖体P蛋白抗体、抗中性粒细胞胞浆抗体在系统性红斑狼疮患者中的表达及临床意义  

Expression and clinical significance of ARPA and ANCA in patients with systemic lupus erythematosus

作　　者：郭骏戈 董玉琳 曹向红 高辉 王胜虎 许丽虹 王萍 GUO Jun-ge;DONG Yu-lin;CAO Xiang-hong;GAO Hui;WANG Sheng-hu;XU Li-hong;WANG Ping(Kunming Yan′an Hospital,Kunming 650051,China)

机构地区：[1]昆明市延安医院,云南昆明650051

出　　处：《实用医院临床杂志》2022年第6期133-136,共4页Practical Journal of Clinical Medicine

摘　　要：目的 分析抗核糖体P蛋白抗体(ARPA)、抗中性粒细胞胞浆抗体(ANCA)在系统性红斑狼疮患者中的表达及临床意义。方法 选取2018年1月至2021年12月我院收治的126例系统性红斑狼疮患者作为研究组,另选取同期健康体检人群82例作为对照组。比较研究组与健康组ARPA、ANCA的表达水平,对比活动期与非活动期期患者ARPA、ANCA的表达。统计系统性红斑狼疮患者肾损害的发生情况并分析其发生的危险因素。结果 研究组ARPA、ANCA阳性表达率均高于对照组(P<0.05);活动组ARPA、ANCA阳性表达均高于非活动组(P<0.05);126例系统性红斑狼疮患者中发生肾损害的67例(53.17%)。肾损害患者疾病活动期占比、抗dsDNA抗体阳性占比、ARPA及ANCA表达水平与非肾损害患者比较,差异有统计学意义(P<0.05)。疾病活动期、抗dsDNA抗体阳性、ARPA阳性、ANCA阳性为影响系统性红斑狼疮患者肾损害发生的危险因素(P<0.05)。结论 ARPA、ANCA在系统性红斑狼疮患者中呈阳性表达,且和病情程度密切相关,是系统性红斑狼疮肾损害发生的危险因素,值得临床进一步研究。Objective To analyze the expression and clinical significance of anti-ribosomal phosphoportein antibodies(ARPA) and antineutrophil cytoplasmic antibodies(ANCA) in patients with systemic lupus erythematosus(SLE).Methods One hundred and twenty-six patients with SLE admitted to our hospital from January 2018 to December 2021 were selected as a research group, and 82 healthy people who underwent physical examination during the same period were selected as a control group. The expression levels of ARPA and ANCA were compared between the two groups. The expression levels of ARPA and ANCA between the active and inactive patients were compared. The incidence of renal damage in patients with SLE was analyzed, and the risk factors of renal damage in patients with SEL were analyzed.Results The positive expression rates of ARPA and ANCA in the research group were higher than those in the control group(P<0.05). The positive expression of ARPA and ANCA in the active group were higher than those in the inactive group(P<0.05). Among 126 patients, 67 cases with SLE had renal damage, and the incidence was 53.17%. There were statistically significant differences in the proportion of patients with active disease, the percentage of positive anti-dsDNA antibodies and the expression levels of ARPA and ANCA in patients with renal injury when compared with those in patients without renal injury(P<0.05). According to the multivariate logistic regression model analysis results, disease active stage, anti-dsDNA antibody positive, ARPA positive, and ANCA positive were the risk factors affecting the occurrence of renal damage in patients with SLE(P<0.05).Conclusions ARPA and ANCA are positive expressions in SLE patients, and are closely related to the severity of the disease. The autoantibodies are risk factors for renal damage in SEL patients. It is worthy of further clinical study.

关 键 词：抗核糖体P蛋白抗体 系统性红斑狼疮 抗中性粒细胞胞浆抗体 临床意义 活动期 

分 类 号：R593.241[医药卫生—内科学] R446.6[医药卫生—临床医学]