基于古籍文献挖掘和网络药理学的《圣济总录·口齿门》揩齿方用药规律及其核心方抗炎机制探析  

Exploration of the Prescription Rule of Kaichi Prescription and Anti-Inflammation Mechanism of the Core Prescription in Compilations of Chinese Medical Formulae Recorded by Imperial Court:Oral Medicine Based on the Excavation of Ancient Literature and Network Pharmacology

作　　者：武凤震 刘菁 朱敏敏[4] 王振国 WU Feng-zhen;LIU Jing;ZHU Min-min;WANG Zhen-guo(Institute of Chinese Medical Literature and Culture,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Key Laboratory for Classical Theory of Traditional Chinese Medicine of Education Ministry,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;Shandong College of Traditional Chinese Medicine,Yantai 264199,China;The First Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250014,China)

机构地区：[1]山东中医药大学中医文献与文化研究院,山东济南250355 [2]山东中医药大学中医药经典理论教育部重点实验室,山东济南250355 [3]山东中医药高等专科学校,山东烟台264199 [4]山东中医药大学第一临床医学院,山东济南250014

出　　处：《南京中医药大学学报》2022年第11期1015-1026,共12页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家重点研发计划(2017YFC1702700);山东省科学技术厅重点研发计划项目(2016CYJS08A01-1)。

摘　　要：目的挖掘《圣济总录·口齿门》揩齿方的用药规律并分析其核心方的抗炎机制。方法收集整理《圣济总录·口齿门》中的揩齿方,对其进行描述性统计分析、高频药对与药组分析、核心方发现分析、核心方抗炎分子机制分析。结果共收集102首揩齿方,方剂以治疗齿龈类疾病为主,其中频数超过5的高频药物有细辛、升麻、皂荚、大青盐、麝香等33种,通过关联规则分析得到46个药对与药组,发现了药物组成为升麻、白芷、细辛、藁本的核心方。核心方中山柰酚、白芷醇等成分可通过作用于PTGS2、PIK3CA、MAPK8等多个靶点影响脂质与动脉粥样硬化、癌症、卡波西肉瘤相关疱疹病毒感染等多条通路发挥抗炎作用。结论揩齿方善用风药,注重祛风止痛、芳香除臭、清热泻火。其核心方发挥抗炎作用具有多成分、多靶点、多通路的特点。OBJECTIVE To excavate the medication rule of Kaichi prescription in Compilations of Chinese Medical Formulae Recorded by Imperial Court:Oral Medicine and analyze the anti-inflammation mechanism of core prescription.METHODS Collect and organize the Kaichi prescription in Compilations of Chinese Medical Formulae Recorded by Imperial Court:Oral Medicine and perform descriptive statistical analysis,analysis of high-frequency Herb pairs and Herb groups,and analysis of core prescription and anti-inflammation mechanism of core prescription.RESULTS A total of 102 Kaichi prescriptions were collected,mainly for the treatment of gingival diseases,with 33 kinds of high-frequency Herbs with a frequency of more than 5,such as Radix et Rhizoma Asari,Rhizoma Cimicifugae,Fructus Gleditsiae,Halitum,Moschus,etc.Forty-six drug pairs and drug groups were obtained by association rule analysis,and the core prescription with herbs composition of Rhizoma Cimicifugae,Radix Angelicae Dahuricae,Radix et Rhizoma Asari and Rhizoma Ligustici was found.The active ingredients of the core prescription,including kaempferol and byakangelicol,can affect lipid and atherosclerosis,pathways in cancer and kaposi sarcoma-associated herpesvirus infection acting on targets such as PTGS2,PIK3CA and MAPK8 to treat inflammation.CONCLUSION The Kaichi prescription makes good use of wind medicine,focusing on dispelling wind and relieving pain,aromatic deodorization,as well as clearing heat and reducing internal heat.The core prescription has the characteristics of multi-components,multi-targets and multi-pathways in the treatment of inflammation.

关 键 词：圣济总录 口齿门 揩齿方 数据挖掘 网络药理学 用药规律 抗炎 

分 类 号：R285.5[医药卫生—中药学]