病毒感染对细胞凋亡影响的研究进展  

Research progress on effect of virus infection on apoptosis

作　　者：杨筱萌 罗语思 张科 YANG Xiao-meng;LUO Yu-si;ZHANG Ke(Key Laboratory of Modern Pathogenicity Biology,Department of Human Parasitology,School of Basic Medical Sciences,Guizhou Medical University,Guiyang 550025,Guizhou Province,China;Department of Emergency,The Affiliated Hospital of Guizhou Medical University)

机构地区：[1]贵州医科大学基础医学院人体寄生虫学教研室,现代病原生物学特色重点实验室,贵州贵阳550025 [2]贵州医科大学附属医院急诊科

出　　处：《热带病与寄生虫学》2022年第5期284-289,共6页Journal of Tropical Diseases and Parasitology

基　　金：国家自然科学基金项目(82160383);贵州省科技计划项目(黔科合支撑〔2020〕4Y163号、黔科合基础-ZK〔2022〕一般432);贵州省卫生健康委科学技术基金项目(gzwkj2021-463、gzwkj2022-230);贵州省中医药管理局科学技术研究专项(QZYY-2021-018);贵阳市科技局科技计划项目(筑科合同〔2020〕-10-2号);贵州医科大学附属医院、贵州医科大学国基培育项目(I-2020-06、20NSP011)。

摘　　要：病毒感染与宿主细胞凋亡之间存在着密切的关系。宿主细胞主动性凋亡引起被感染细胞死亡,同时达到清除病毒的效果,在机体防御病毒感染中起重要作用;病毒亦主动诱导或抑制宿主细胞凋亡,从而达到在机体内复制产生更多子代病毒并完成生活周期的目的,并造成持续性感染或肿瘤发生。本文对细胞凋亡与病毒感染关系相关研究进行综述,为病毒感染性疾病的发病机制、治疗和抗病毒制剂研究提供新思路。Virus infection is in close relationship with apoptosis of the host.Apoptosis of the infected host cells plays critical roles in the defense of virus invading.The active apoptosis of the host cells leads to the death of infected cells and then the clearance of virus.Meanwhile,in order to replicate more vial progenies and complete the viral life cycle in the host cells,inducing or inhibiting the apoptosis in host cells by virus would result in the occurrence of related-diseases,for example the persistent infection and tumor.This paper primarily reviewed the relationship between viral infection and apoptosis,with an attempt to provide novel ideas for exploring the pathogenesis of viral infectious diseases and developing new antiviral agents.

关 键 词：细胞凋亡 病毒感染 诱导凋亡 抑制凋亡 

分 类 号：R373.1[医药卫生—病原生物学] R730[医药卫生—基础医学]