RSV感染所致反复喘息婴幼儿血清25(OH)D_(3)水平及API变化的临床意义  

Clinical significance of the changes of serum 25(OH)D_(3) level and API in infants and children with recurrent wheezing due to RSV infection

作　　者：任天思 郭秀玲[1] 李然 王艳录 杨磊 REN Tiansi;GUO Xiuling;LI Ran;WANG Yanlu;YANG Lei(Department of Pediatrics,Handan Central Hospital(East District),Handan,Hebei 056001,China)

机构地区：[1]邯郸市中心医院(东区)儿内科,河北邯郸056001

出　　处：《国际检验医学杂志》2022年第22期2701-2705,共5页International Journal of Laboratory Medicine

基　　金：河北省医学科学研究课题(20220554)。

摘　　要：目的 探讨呼吸道合胞病毒(RSV)感染所致反复喘息婴幼儿(简称患儿)血清25-羟维生素D[25(OH)D_(3)]水平及哮喘预测指数(API)变化的临床意义。方法 选取该院2020年3月至2021年6月收治的102例RSV感染所致反复喘息患儿作为研究组,另选同期51例RSV所致毛细支气管炎患儿作为对照组。比较研究组与对照组血清25(OH)D水平,比较研究组不同病情严重程度、再次喘息与未再次喘息患儿血清25(OH)D水平及API阳性率,比较不同API患儿血清25(OH)D_(3)水平,分析血清25(OH)D_(3)水平、API、病情严重程度间的相关性,以及血清25(OH)D_(3)、API对RSV感染所致反复喘息患儿6个月内再次喘息的预测价值。结果 研究组血清25(OH)D_(3)水平低于对照组(P<0.05)。血清25(OH)D_(3)水平比较,重度组低于中度、轻度组(P<0.05),中度组低于轻度组(P<0.05);API阳性率比较,重度组高于中度、轻度组(P<0.05),中度组高于轻度组(P<0.05)。研究组血清25(OH)D_(3)水平与病情严重程度呈负相关(r=-0.706,P<0.05),API阳性率与病情严重程度呈正相关(r=0.712,P<0.05)。API阳性组血清25(OH)D_(3)水平低于API阴性组(P<0.05),研究组血清25(OH)D水平与API阳性呈负相关(r=-0.743,P<0.05)。再次喘息组血清25(OH)D_(3)水平低于未再次喘息组(P<0.05),而API阳性率高于未再次喘息组(P<0.05)。血清25(OH)D_(3)缺乏RSV感染所致反复喘息患儿6个月内再次喘息的相对危险度是25(OH)D_(3)正常患儿的6.000(95%CI:2.041~17.641)倍,API阳性RSV感染所致反复喘息患儿6个月内再次喘息的相对危险度是API阴性患儿的7.091(95%CI:0.966~52.030)倍。血清25(OH)D_(3)、API联合预测RSV感染所致反复喘息患儿6个月内再次喘息的受试者工作特征曲线下面积为0.881(95%CI:0.694~0.861),大于二者单独预测。结论 RSV感染所致反复喘息患儿血清25(OH)D_(3)水平及API变化与喘息发生、发展密切相关,25(OH)D_(3)缺乏和API阳性会明显增加再次喘息风�Objective To investigate the clinical significance of the changes of serum 25-hydroxyvitamin D[25(OH)D_(3)] level and asthma predictive index(API) in infants and children(referred to as children) with recurrent wheezing caused by respiratory syncytial virus(RSV) infection.Methods A total of 102 children with recurrent wheezing caused by RSV infection who were admitted to this hospital from March 2020 to June 2021 were selected as the study group, and 51 children with bronchiolitis caused by RSV during the same period were selected as the control group.The serum 25(OH)D_(3)levels of the study group and the control group were compared, and the serum 25(OH)D_(3)level and API positive rate of children with different disease severity, and re-wheezing and no re-wheezing in the study group were compared.The serum 25(OH)D_(3)levels in children with different API were compared.The correlation among serum 25(OH)D_(3)level, API and disease severity, and the predictive value of serum 25(OH)D_(3)and API on re-wheezing within 6 months in children with recurrent wheezing caused by RSV infection were analyzed.Results The serum 25(OH)D_(3)level in the study group was lower than that in the control group(P<0.05).Comparison of serum 25(OH)D_(3)levels, the severe group was lower than the moderate and mild group(P<0.05),and the moderate group was lower than the mild group(P<0.05);comparison of API positivity rates, the severe group was higher than the moderate and mild group(P<0.05),and the moderate group was higher than the mild group(P<0.05).The serum 25(OH)D_(3)level in the study group was negatively correlated with the severity of the disease(r=-0.706,P<0.05),and the positive rate of API was positively correlated with the severity of the disease(r=0.712,P<0.05).The serum 25(OH)D_(3)level in the API-positive group was lower than that in the API-negative group(P<0.05),and the serum 25(OH)D_(3)level was negatively correlated with API positivity in the study group(r=-0.743,P<0.05).The serum 25(OH)D_(3)level in the re-wheezing group w

关 键 词：呼吸道合胞病毒 反复喘息 25羟维生素D_(3) 哮喘预测指数 

分 类 号：R725.6[医药卫生—儿科]