2型糖尿病周围神经病变的影响因素分析  

Analysis of Influencing Factors of Peripheral Neuropathy in Type 2 Diabetes

作　　者：万芳[1] WAN Fang(Department of Endocrinology,Jiujiang First People's Hospital,Jiujiang 332000,China)

机构地区：[1]九江市第一人民医院内分泌科,江西九江332000

出　　处：《中国医药指南》2022年第31期69-71,75,共4页Guide of China Medicine

基　　金：江西省卫生健康委员会科技计划项目(项目编号:20204175)。

摘　　要：目的研究2型糖尿病周围神经病变的影响因素。方法收集2021年1月至2022年5月在我院内分泌科住院的181例2型糖尿病(T2DM)患者,据患者是否并发2型糖尿病周围神经病变(DPN)将其分为观察组(T2DM合并DPN,n=75)与对照组(T2DM未合并DPN,n=106)。收集测定两组患者年龄、性别、病程、BMI指数、SBP、DBP、WBC、UACR、Scr、SUA、TG、LDL-C、HDL-C、HbA_(1)c、FPG、2hPG、FC-P、2hC-P等指标。计算稳态模型胰岛素抵抗(HOMA-IR)指数、LAGE(最大血糖波动幅度)、PPGE(餐后血糖波动幅度)、SDBG(血糖水平标准差)。采用单因素分析DPN相关危险因素,采用Logistic回归分析发生DPN的危险因素。结果两组患者的资料比较,病程、BMI指数、收缩压、糖化血红蛋白、空腹胰岛素、空腹C肽、HOMA-IR、TG、HDL-C、Scr、SUA、FBG、LAGE、PPGE、SDBG、性别比较,差异无统计学意义(P>0.05)。观察组年龄、NLR高于对照组,餐后2 h胰岛素、餐后2 h C肽、舒张压水平明显低于对照组,差异有统计学意义(P<0.05)。Logistic回归分析提示:年龄、NLR是DPN的危险因素。结论本研究提示随着年龄的增长、NLR水平的升高,糖尿病周围神经病变风险增高;年龄、NLR是DPN的危险因素。Objective To investigate the risk factors for peripheral neuropathy in type 2 diabetes.Methods A total of 181 patients with type 2 diabetes mellitus admitted to our department of endocrinology from January to May 2022 were 2021,the patients were divided into observation group(DPN group,n=75)and control group(non-DPN group,n=106).Age,sex,course of disease,BMI index,SBP,DBP,WBC,UACR,Scr,SUA,TG,LDL-C,HDL-C,HbA_(1)c,FPG,2HPG,FC-P,2hC-P were measured.Homeostasis model assessment of insulin resistance(HOMA-IR),maximum fluctuation range of blood glucose(LAGE),average fluctuation range of postprandial blood glucose(PPGE)and standard deviation of blood glucose(SDBG)were calculated.Single factor analysis was used to analyze DPN related risk factors,and logistic regression was used to analyze DPN related risk factors.Results The data of the two groups were compared,course of disease,BMI index,systolic blood pressure,Glycated hemoglobin,fasting insulin,fasting C-peptide,HOMA-IR,TG,HDL-C,Scr,SUA,FBG,LAGE,PPGE,SDBG,and sex were compared,there was no significant difference(P>0.05).The age and NLR of the observation group were higher than those of the control group,and the levels of insulin,C-peptide and diastolic blood pressure were significantly lower than those of the control group at 2 hours after meal(P<0.05).Logistic regression analysis showed that age and NLR were the risk factors of diabetic peripheral neuropathy.Conclusion This study suggests that the risk of diabetic peripheral neuropathy increases with age and NLR levels,and that age and NLR are risk factors for diabetic peripheral neuropathy.

关 键 词：2型糖尿病 糖尿病周围神经病变 年龄 NLR 

分 类 号：R587.1[医药卫生—内分泌]