补肾方药治疗绝经后骨质疏松症患者的效果及对OPG、IGF-Ⅰ、E_(2)指标的影响  

Effect of Kidney Tonic Prescription in the Treatment of Postmenopausal Osteoporosis Patients and its Effect on OPG,IGF-Ⅰ,E_(2) Indexes

作　　者：钟发明[1] 徐王兵[1] 李勇[1] 汤敏予[1] 张法慈 ZHONG Faming;XU Wangbing;LI Yong;TANG Minyu;ZHANG Faci(Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine,Nanchang 330006,China;Xingguo County Hospital of Traditional Chinese Medicine,Ganzhou 342400,China)

机构地区：[1]江西中医药大学附属医院,江西南昌330006 [2]兴国县中医院,江西赣州342400

出　　处：《中国医药指南》2022年第31期126-129,共4页Guide of China Medicine

基　　金：江西省教育厅科技项目(课题编号:GJJ211218)。

摘　　要：目的探讨补肾方药治疗绝经后骨质疏松症患者的疗效及对OPG、IGF-Ⅰ、E_(2)指标的影响。方法选取江西中医药大学附属医院住院部2017年1月至2021年2月接收治疗绝经后骨质疏松症患者240例为观察对象,随机将其分为观察组与对照组,其中对照组120例采用常规治疗方法,观察组120例采用补肾方药治疗,将两组患者治疗前后OPG(血清骨保护素)、IGF-Ⅰ(胰岛素样生长因子-Ⅰ)、E_(2)(血清雌二醇)以及骨密度与骨代谢指标、并发症发生情况、生活质量以及治疗效果进行比较。结果治疗前两组患者OPG、IGF-Ⅰ、E_(2)、骨密度及骨代谢指标、生活质量评估量表(SF-36)评分差异不显著(P>0.05),治疗后观察组OPG低于对照组,IGF-Ⅰ、E_(2)、骨密度、骨碱性磷酸酶、N端骨钙素以及SF-36评分均高于对照组,数据对比差异有统计学意义(P<0.05);观察组并发症发生情况低于对照组,治疗总有效率高于对照组,数据对比差异有统计学意义(P<0.05)。结论补肾方药对绝经后骨质疏松症治疗效果明显,能有效降低OPG指标,提高IGF-Ⅰ、E_(2)指标,从而改善生活质量,降低并发症发生,促进康复,值得推广与应用于临床治疗中。Objective To investigate the efficacy of kidney tonic prescription in the treatment of postmenopausal osteoporosis patients and their effects on OPG,IGF-Ⅰand E_(2) indexes.Methods select our 2017-2021 in postmenopausal osteoporosis patients,randomly divided into observation group and control group,control group(n=120)using kidney prescription,observation group(n=120)before and after the patients OPG(osteoprotectin),IGF-Ⅰ(insulin-like growth factor-Ⅰ),E_(2)(estradiol 2),bone density and bone metabolism,complications,quality of life and treatment effect are compared.Results There was no significant difference in the scores of OPG,IGF-I,E_(2),bone mineral density and bone metabolism index,and quality of life assessment scale(SF-36)between the two groups(P>0.05),the OPG of the observation group after treatment was lower than that of the control group,and the scores of IGF-Ⅰ,E_(2),bone mineral density,bone alkaline phosphatase,N-Osrteo and SF-36 were higher than those in the control group,and the difference in data comparison was statistically significant(P<0.05).The incidence of complications in the observation group was lower than that in the control group,and the total effective rate of treatment was higher than that in the control group,and the difference in data comparison was statistically significant(P<0.05).Conclusion Kidney tonic prescription on postmenopausal osteoporosis,it can effectively reduce OPG index,improve IGF-Ⅰ,E_(2) indexes,thereby improve quality of life,reduce complications and promote rehabilitation,which is worth popularizing and applying in clinical treatment.

关 键 词：补肾方药 绝经后骨质疏松症 OPG指标 影响效果 

分 类 号：R681[医药卫生—骨科学]