新城疫病毒作为人和动物传染病疫苗载体的研究进展  

Research Progress of Newcastle Disease Virus as a Vaccine Vector Against Human and Animal Infectious Diseases

作　　者：王国康 李丽 贾妙妙 樊三铃 冯贺龙 商雨[1,2] 曾驰 温国元 WANG Guo-kang;LI Li;JIA Miao-miao;FAN San-ling;FENG He-long;SHANG Yu;ZENG Chi;WEN Guo-yuan(Institute of Animal Husbandry and Veterinary,Hubei Academy of Agricultural Sciences,Wuhan 430064,China;Key Laboratory of Prevention and Control Agents for Animal Bacteriosis(Ministry of Agriculture and Rural Affairs),Wuhan,Hubei,430064,China;School of Biology and Pharmaceutical Engineering,Wuhan Polytechnic University,Wuhan 430023,China)

机构地区：[1]湖北省农业科学院畜牧兽医研究所,武汉430064 [2]农业农村部畜禽细菌病防治制剂创制重点实验室,武汉430064 [3]武汉轻工大学生物与制药工程学院,武汉430023

出　　处：《中国动物传染病学报》2022年第5期176-182,共7页Chinese Journal of Animal Infectious Diseases

基　　金：国家自然科学基金项目(31670157,31873018);国家重点研发计划(2017YFD0501104);国家现代农业产业技术体系建设专项资金(CARS-41-G13);湖北省自然科学基金杰出青年人才项目(2019CFA071);湖北省对外科技合作项目(2019AHB066)。

摘　　要：新城疫病毒(NDV)是一种有囊膜的、单股负链RNA病毒,属副黏病毒科、正肺病毒属。其作为新城疫(ND)的病原,可引起包括家禽、水禽、候鸟在内的多种家禽和鸟类发病死亡。反向遗传学技术发展至可操作负链非节段RNA病毒之后,NDV已被作为疫苗载体用于开发各种疫苗。本文简要综述了NDV的基本信息、分子生物学特征以及其反向遗传系统,重点概述了NDV作为人和动物疫苗载体的研究进展。Newcastle disease(ND)is one of the most important avian diseases and poses considerable threat to poultry industry worldwide.The Newcastle disease virus(NDV)infects a variety of poultry,waterfowl and migratory birds and is an enveloped virus with single-stranded,negative-sense RNA genome belonging to genus Orthoavulavirus,family Paramyxoviridae.Development of infectious cDNA clones of NDV has enable genetic approaches for developing vaccine vectors for other pathogens.Here,we briefly summarized the basic information,molecular biological characteristics of NDV,application of reverse genetic system and research progress of NDV as a vector for development of human and animal vaccines.

关 键 词：新城疫病毒 反向遗传技术 载体 疫苗 

分 类 号：S852.65[农业科学—基础兽医学]