Formulation and Evaluation of Yemeni Potash Alum as Hydrophilic Topical Preparations against Candidiasis and Aspergillosis  

作　　者：Moath Refat Anes A.M.Thabit Abdul-Rahman Maqboli Hesham Siddick Rafaʼa MAl-Ghozee Abdul-baqi A.Thabet Manar Refat Aiman Saleh A.Mohammed Ahmed Al-Sabati Wu Xin’an 

机构地区：[1]College of Pharmaceutical Science,Lanzhou University,Lanzhou 730000,Gansu,China [2]Department of Pharmacy,The First Hospital of Lanzhou University,Lanzhou 730000,Gansu,China [3]College of Pharmacy,University of Science and Technology,Al-Hodeidah,15201,Yemen [4]College of Medical Sciences,University of Science and Technology,Al-Hodeidah,15201,Yemen [5]College of Pharmacy,Sana’a University,Sana’a,1247,Yemen [6]Pharmacy department,Al-Razi University,Sana’a,Yemen [7]Department of Pharmacology,Faculty of Pharmacy,University of Aden,Aden,6312,Yemen

出　　处：《Clinical Complementary Medicine and Pharmacology》2022年第4期26-38,共13页临床补充医学和药理学（英文）

摘　　要：Background:Skin and soft tissue infections are frequent.Candidiasis and Aspergillosis are the most common cutaneous fungal infections.Yemeni alum(Aluminium Potassium Sulphate)is a natural mineral with antifungal and antibacterial properties.Objective:This study aimed to confirm Yemeni alum’s antifungal effectiveness against selected fungal strains and develop useful topical formulations.Methods:Using different alum concentrations,we prepared twenty-three formulations,including four non-adjusted aqueous solutions,eight adjusted pH aqueous solutions,eight glycerite solutions,and three Oil/Water cream formulations.Then,we examined the antifungal activity against the suggested fungus.The animal skin irritation test evaluated the local skin sensitivity reactions that might happen upon using the formulations we pre-pared on the intact animal’s skin.Additionally,this study also included six weeks of stability testing to estimate the expected shelf life(t90)of the selected formulations.Results:Alum exerted antifungal effect against Candida albicans,Aspergillus niger,and Aspergillus flavus.The animal’s skin was not irritated by any of the formulations examined.The 5%alum aqueous solution and the 10%alum Oil/Water cream exhibited promising results among all tested formulations.The approximate formulation’s shelf-lives(t90)were 2 and 1.52 years with alum content(%)ranging between 105.75%to 106.02%,respectively.Conclusion:Based on the results we found,10%alum Oil/Water cream is a promising formulation for large-scale manufacture.

关 键 词：Potassium alum Yemeni alum ANTIFUNGAL Topical preparations Skin soft tissue infections CANDIDIASIS ASPERGILLOSIS 

分 类 号：R519[医药卫生—内科学]