不同促排卵方案在多囊卵巢综合征所致不孕症患者中的临床效果对比  

Comparison of clinical effects of different ovulation induction schemes in infertility patients with polycystic ovary syndrome

作　　者：齐艳红 刘晓光 苑娜 Qi Yanhong;Liu Xiaoguang;Yuan Na(Department of Obstetrics and Pediatrics,PLA 968th Hospital,Jinzhou 121001,China;95905 Unit,Jinzhou 121001,China)

机构地区：[1]辽宁省锦州市解放军第968医院妇儿科,辽宁锦州121001 [2]95905部队,辽宁锦州121001

出　　处：《实用妇科内分泌电子杂志》2021年第28期45-47,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的探讨不同促排卵方案在多囊卵巢综合征(PCOS)所致不孕症患者中的临床效果。方法选取64例PCOS所致不孕症患者,采用随机数字表法分为A组与B组,各32例。A组采用来曲唑治疗,B组采用枸橼酸氯米芬治疗。对比两组治疗效果。结果治疗前,两组卵泡刺激素(FSH)、促黄体生成素(LH)及雌二醇(E_(2))水平比较,差异无统计学意义(P>0.05);治疗后,两组FSH、LH及E_(2)水平均有所降低,且A组明显低于B组,差异具有统计学意义(P<0.05)。A组患者排卵率93.75%、妊娠率40.63%均高于B组的65.63%、9.38%,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论针对PCOS所致不孕症患者,相比枸橼酸氯米芬,来曲唑促排卵效果更加明显,妊娠率高,值得临床推广与应用。Objective To investigate the clinical effect of different ovulation induction regimens in infertile patients with polycystic ovary syndrome(PCOS).Methods 64 infertility patients with PCOS were selected and divided into group A and group B by random number table method,32 cases in each group.Group A was treated with Letrozole and group B was treated with clomiphene citrate.The treatment effects of the two groups were compared.Results Before treatment,there was no significant difference in the levels of follicle-stimulating estrogen(FSH),luteinizing hormone(LH)and estradiol(E2)between the two groups(P>0.05).After treatment,the levels of FSH,LH and E2 in the two groups were decreased,and the levels in group A were significantly lower than those in group B,and the differences were statistically significant(P<0.05).The ovulation rate of 93.75%and pregnancy rate of 40.63%in group A were higher than 65.63%and 9.38%in group B,and the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion For PCOS infertile patients,compared with clomiphene citrate,Letrozole has more obvious ovulation promotion effect and higher pregnancy rate,which is worthy of clinical promotion and application.

关 键 词：多囊卵巢综合征 不孕症 促排卵 来曲唑 枸橼酸氯米芬 

分 类 号：R711.75[医药卫生—妇产科学] R711.6[医药卫生—临床医学]