膏方辅助治疗高血压疗效和安全性的Meta分析  

A Meta-analysis of the Efficacy and Safety of Chinese Herbal Paste as Adjuvant Treatment of Hypertension

作　　者：何敬爽 刘琴 李林蔓[1] 吴科锐[1] 老膺荣[3] HE Jingshuang;LIU Qin;LI Linman;WU Kerui;LAO Yingrong(The Second Clinical College of Guangzhou University of Chinese Medicine,Guangzhou 510405,Guangdong,China;Dongcheng District Community Health Service Management Center of Beijing Municipality,Beijing 100010,China)

机构地区：[1]广州中医药大学第二临床医学院,广州510405 [2]北京市东城区社区卫生服务管理中心,北京100010 [3]广东省中医院名中医学术传承与创新研究团队,广州510120

出　　处：《中西医结合心脑血管病杂志》2022年第21期3864-3870,共7页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：国家中医药管理局龙砂医学流派传承基地建设项目,编号:国中医药人教函[2012]228号;广东省中医院顾植山学术经验传承工作室项目,编号:广中医文[2014]089号。

摘　　要：目的 系统评价膏方辅助治疗高血压的疗效和安全性。方法 检索中国生物医学文献数据库(CBM)、万方数据库、中国知网数据库(CNKI)、维普全文期刊数据库(VIP)、the Cochrane Library、PubMed以及EMbase。检索时限为建库至2020年12月9日,收集膏方辅助治疗高血压的随机对照试验(RCT)。由2名研究人员分别对纳入的文献进行资料提取、质量评价,借助RevMan 5.3软件进行Meta分析。结果 共纳入10篇文献,涉及822例病人,其中治疗组(膏方与常规西药治疗联合治疗)412例,对照组(常规西药治疗)410例。Meta分析显示:治疗组降压疗效[OR=3.52,95%CI(1.94,6.41),P<0.000 1]、中医临床症状疗效[OR=8.46,95%CI(5.42,13.19),P<0.000 01]均优于对照组,治疗组治疗后中医证候积分低于对照组[MD=-5.10,95%CI(-6.64,-3.56),P<0.000 01];但两组在降低收缩压[MD=-1.26,95%CI(-4.81,2.30),P=0.49]、舒张压[MD=-0.89,95%CI(-4.44,2.66),P=0.62]方面差异均无统计学意义。结论 现有研究表明:采用膏方辅助治疗高血压可改善中医临床症状,且安全性较好,但在降压方面没有明显优势。Objective To evaluate the efficacy and safety of Chinese herbal paste as adjuvant treatment of hypertension.Methods Chinese Biomedical Literature Database(CBM),WanFang Data, CNKI,VIP,PubMed, EMbase, and the Cochrane Library were electronically searched to collect randomized controlled trials(RCTs) of Chinese herbal paste as adjuvant treatment of hypertension from inception to December, 2020. Two reviewers screened literature independently, extracted data, and assessed the risk of bias of included studies, then RevMan 5.3 software was used for data analysis.Results Ten RCTs involving 822 participants were included, with 412 cases in intervention group(paste prescription combined with western medicine) and 410 cases in control group(western medicine).Intervention group was better than control group in the efficacy of the blood pressure[OR=3.52,95%CI(1.94,6.41),P<0.000 1],clinical efficacy of traditional Chinese medicine symptoms[OR=8.46,95%CI(5.42,13.19),P<0.000 01],and traditional Chinese medicine syndrome score[MD=-5.10,95%CI(-6.64,-3.56),P<0.000 01],but there was no significant difference in reducing systolic pressure[MD=-1.26,95%CI(-4.81,2.30),P=0.49] and diastolic pressure[MD=-0.89,95%CI(-4.44,2.66),P=0.62].Conclusion The available evidence suggests that Chinese herbal paste as adjuvant treatment of hypertension, can improve clinical symptoms with good safety, but there is no obvious advantage in lowering blood pressure.

关 键 词：高血压 膏方 中医证候积分 META分析 

分 类 号：R544.1[医药卫生—心血管疾病]