预防产后出血中使用缩宫素联合米索前列醇的治疗效果及保健策略  

Therapeutic effect of oxytocin combined with misoprostol in preventing postpartum hemorrhage and corresponding health care strategies

作　　者：范霞 Fan Xia(Obstetrics Department,Zhengzhou People's Hospital(People's Hospital of Henan University of Traditional Chinese Medicine),Zhengzhou,Henan 450003,China)

机构地区：[1]郑州人民医院(河南中医药大学人民医院)产科,河南郑州450003

出　　处：《实用妇科内分泌电子杂志》2021年第21期37-39,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的 探讨预防产后出血中使用缩宫素联合米索前列醇的治疗效果以及相对应保健策略。方法 选取80例有出血风险的高危孕妇,按照随机数字表法分为常规组和试验组,每组均40例。常规组采用缩宫素预防治疗,试验组在常规组基础上联合米索前列醇治疗,两组均采取对应的保健措施。比较两组治疗前后的血浆凝血酶时间(TT)、活化部分凝血活酶原时间(APTT)、纤维蛋白原(FIB)。结果 与治疗前比,治疗后两组TT、APTT均缩短,试验组短于常规组;FIB水平均降低,试验组低于常规组;试验组产后2 h、24 h的出血量均明显低于常规组,差异具有统计学意义(P<0.05)。结论预防产妇产后出血中联合使用缩宫素和米索前列醇治疗,能有效改善产妇子宫收缩乏力的状况,改善凝血功能,减少产后出血量。Objective To explore the therapeutic effect of oxytocin combined with misoprostol in the prevention of postpartum hemorrhage and the corresponding health care strategies. Methods A total of 80 high-risk pregnant women with bleeding risk were selected and divided into a routine group and an experimental group according to the random number table method, with 40 cases in each group. The routine group was treated with oxytocin for prophylaxis, while the experimental group was treated with misoprostol on the basis of the routine group, and corresponding health care measures were taken for the puerperae in the two groups. The plasma thrombin time(TT), activated partial thromboplastin time(APTT) and fibrinogen(FIB) were compared between the two groups before and after treatment. Results Compared with before treatment, the TT and APTT of the two groups shortened after treatment, and the experimental group was shorter than the routine group;the FIB levels decreased, and the experimental group was lower than the routine group;the bleeding volume at 2 h and 24 h postpartum in the experimental group were significantly lower than that of the routine group, the differences were statistically significant(P<0.05). Conclusion Combined use of oxytocin and misoprostol in the prevention of postpartum hemorrhage can effectively improve maternal uterine atony, improve coagulation function, and reduce postpartum hemorrhage.

关 键 词：缩宫素 米索前列醇 产后出血 凝血功能 

分 类 号：R714.461[医药卫生—妇产科学]