益肾养胎活血方联合地屈孕酮治疗先兆流产合并宫腔积血的临床研究  

Clinical study of Yishen Yangtai Huoxue Decoction Combined with didroxyprogesterone in the treatment of threatened abortion with uterine hematocele

作　　者：袁媛[1] 齐丹[1] Yuan Yuan;Qi Dan(Department of traditional Chinese medicine,maternity hospital affiliated to Nanjing Medical University(Nanjing Maternal and child health hospital)Nanjing Medical University,Nanjing 210000,China)

机构地区：[1]南京医科大学附属妇产医院(南京市妇幼保健院)中医科,江苏南京210000

出　　处：《实用妇科内分泌电子杂志》2021年第18期47-50,共4页Electronic Journal of Practical Gynecological Endocrinology

基　　金：江苏省中医药管理局项目(编号YB2015074)。

摘　　要：目的探讨益肾养胎活血方联合地屈孕酮治疗先兆流产合并宫腔积血的临床疗效。方法选取73例先兆流产合并宫腔积血患者,依据治疗方法不同分为对照组(36例)与治疗组(37例)。对照组采用地屈孕酮治疗,治疗组在对照组基础上联合益肾养胎活血方治疗。比较两组临床疗效、治疗前后中医证候评分、宫腔积血面积、性激素水平、凝血功能及不良反应发生情况。结果治疗组总有效率为91.89%,明显高于对照组的72.22%,差异具有统计学意义(P<0.05)。治疗前,两组中医证候积分、宫腔积血面积、孕酮及雌二醇水平比较,差异无统计学意义(P>0.05);治疗后,两组中医证候评分、孕酮及雌二醇水平均低于治疗前,宫腔积血面积小于治疗前,且治疗组中医证候评分、孕酮及雌二醇水平均低于对照组,宫腔积血面积小于对照组,差异有统计学意义(P<0.05)。治疗前,两组凝血活酶原时间、活化部分凝血活酶时间及D-二聚体指标比较,差异无统计学意义(P>0.05);治疗后,两组凝血活酶原时间、活化部分凝血活酶时间均长于治疗前,D-二聚体指标低于治疗前,且治疗组凝血活酶原时间、活化部分凝血活酶时间均长于对照组,D-二聚体指标低于对照组,差异具有统计学意义(P<0.05)。治疗期间两组肝、肾功能等均未见明显异常,且胃肠道均未发生明显反应及过敏反应。结论益肾养胎活血方联合地屈孕酮治疗先兆流产合并宫腔积血疗效显著,可明显缓解患者症状,值得临床推广与应用。Objective To explore the clinical efficacy of Yishen Yangtai Huoxue Decoction Combined with didroxyprogesterone in the treatment of threatened abortion with uterine hematocele.Methods 73 cases of threatened abortion with hematocele in uterine cavity were selected and divided into control group(36 cases)and treatment group(37 cases)according to different treatment methods.The control group was treated with didroxyprogesterone,and the treatment group was treated with Yishen Yangtai Huoxue Decoction on the basis of the control group.The clinical efficacy,TCM syndrome score,uterine hematocele area,sex hormone level,coagulation function and adverse reactions were compared between the two groups before and after treatment.Results The total effective rate of the treatment group was 91.89%,which was significantly higher than that of the control group(72.22%),the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in TCM syndrome score,intrauterine hematocele area,progesterone and estradiol levels between the two groups(P>0.05).After treatment,the TCM syndrome score,progesterone and estradiol levels in both groups were lower than before,and the area of intrauterine hematocele was smaller than before,and the TCM syndrome score,progesterone and estradiol levels in the treatment group were lower than the control group,and the area of intrauterine hematocele was smaller than the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in prothrombin time,activated partial thrombin time and D-dimer index between the two groups(P>0.05).After treatment,the prothrombin time and activated partial thrombin time in both groups were longer than before,and the D-dimer index was lower than before,and the prothrombin time and activated partial thrombin time in the treatment group were longer than the control group,and the D-dimer index was lower than the control group,the difference was statistically significant(P<0.05).T

关 键 词：先兆流产 宫腔积血 益肾养胎活血 地屈孕酮 

分 类 号：R714.21[医药卫生—妇产科学]