丙硫氧嘧啶治疗妊娠期甲亢的效果与不良反应分析  

Effect and adverse reaction analysis of propyl thiouracil in the treatment of hyperthyroidism in pregnancy

作　　者：周桂敏 Zhou Guimin(Department of Endocrinology,Mudanjiang Cardiovascular Hospital,Mudanfiang 157000,China)

机构地区：[1]牡丹江心血管病医院内分泌一科,黑龙江牡丹江157000

出　　处：《实用妇科内分泌电子杂志》2021年第25期64-66,共3页Electronic Journal of Practical Gynecological Endocrinology

摘　　要：目的分析与甲巯咪唑治疗方案相比,丙硫氧嘧啶治疗妊娠期甲状腺功能亢进症(甲亢)患者的效果及不良反应发生情况。方法选取30例妊娠期甲亢患者,按照入院前后顺序,将前15例患者纳入对照组,实施甲巯咪唑治疗,后15例患者纳入研究组,实施丙硫氧嘧啶治疗。对比两组患者临床疗效及不良反应发生情况。结果研究组治疗总有效率为100%,明显高于对照组的73.33%,差异有统计学意义(P<0.05)。研究组不良反应发生率为6.67%,对照组为13.33%,比较差异无统计学意义(P>0.05)。结论丙硫氧嘧啶治疗妊娠期甲亢患者效果显著,安全性较高,值得临床推广与应用。Objective To analyze the efficacy and adverse reactions of propyl thiouracil in the treatment of hyperthyroidism during pregnancy compared with methimazole.Methods 30 patients with hyperthyroidism during pregnancy were selected.According to the order before and after admission,the first 15 patients were included in the control group and treated with methimazole,and the last 15 patients were included in the study group and treated with propylthiouracil.The clinical efficacy and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 100%,which was significantly higher than that of the control group(73.33%),and the difference was statistically significant(P<0.05).The incidence of adverse reactions was 6.67%in the study group and 13.33%in the control group,and the difference was not statistically significant(P>0.05).Conclusion Propyl thiouracil is effective and safe in the treatment of hyperthyroidism during pregnancy,which is worthy of clinical promotion and application.

关 键 词：妊娠期 甲状腺功能亢进症 甲巯咪唑 丙硫氧嘧啶 临床疗效 

分 类 号：R714.256[医药卫生—妇产科学]