老年高血压病人合并射血分数保留的心力衰竭的临床特征及相关危险因素分析  

Analysis of clinical characteristics and related risk factors of heart failure with preserved ejection fraction in elderly patients with hypertension

作　　者：张铭瑞 崔雯霞 高蕾 李曼 胡云[1] ZHANG Ming-rui;CUI Wen-xia;GAO Lei;LI Man;HU yun(Department of Geriatrics,Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University,Nanjing 210008,China)

机构地区：[1]南京医科大学附属鼓楼临床医学院老年科,江苏省南京市210008

出　　处：《实用老年医学》2022年第12期1247-1250,共4页Practical Geriatrics

基　　金：江苏省老年健康科研项目(LR2021038)。

摘　　要：目的探讨老年高血压合并射血分数保留的心力衰竭(HFpEF)的临床特点及其相关危险因素。方法纳入569例老年高血压住院病人,根据是否合并HFpEF分为HFpEF组和对照组,比较2组间临床特点的差异;采用多元Logistic回归分析老年高血压病人发生HFpEF的影响因素。结果HFpEF组年龄、女性比例、超重、2型糖尿病患病率、血清B型尿钠肽、尿素氮、肌酐水平显著高于对照组(P<0.05)。HFpEF组舒张期室间隔厚度、舒张期左心室内径、舒张期左心室后壁厚度、左心房内径、左心室质量指数均显著高于对照组(P<0.01)。Logistic回归分析显示,老年高血压合并HFpEF的相关危险因素包括女性、超重、2型糖尿病及左心室质量指数。结论女性、超重、2型糖尿病、左心室质量指数是老年高血压病人合并HFpEF的相关危险因素。Objective To investigate the clinical characteristics and related risk factors of heart failure with preserved ejection fraction(HFpEF)in the elderly patients with hypertension.Methods A total of 569 elderly patients with hypertension were enrolled in this study.According to whether presenting with HFpEF,the patients were divided into HFpEF group and control group.The clinical characteristics of the two groups were analyzed.Multiple Logistic regression was used to analyze the risk factors of HFpEF in the elderly patients with hypertension.Results The age,proportion of female,overweight,type 2 diabetes mellitus,serum levels of B type natriuretic peptide,urea nitrogen and creatinine in HFpEF group were significantly higher than those in control group(P<0.05).The diastolic ventricular septal thickness,diastolic left ventricular diameter,diastolic left ventricular posterior wall thickness,left atrial diameter and left ventricular mass index in HFpEF group were significantly higher than those in control group(P<0.01).Logistic regression analysis showed that the related risk factors of HFpEF in the elderly hypertensive patients included female,overweight,type 2 diabetes mellitus and left ventricular mass index.Conclusions The incidence of HFpEF might be influenced by gender,overweight,type 2 diabetes mellitus and left ventricular mass index in the elderly hypertensive patients.

关 键 词：高血压 射血分数保留的心力衰竭 临床特征 

分 类 号：R541.6[医药卫生—心血管疾病] R544.11[医药卫生—内科学]