孕妇生殖道支原体检测及药敏结果分析  

An Analysis of the Detection and Drug Sensitivity of Mycoplasma in Reproductive Tract of Pregnant Women

作　　者：郝洪超 曹正 翟燕红[1] 曾甲子[1] 章京楠 朱宏远[1] 吕娜[2] HAO Hongchao;CAO Zheng;ZHAI Yanhong;ZENG Jiazi;ZHANG Jingnan;ZHU Hongyuan;LYU Na(Clinical Laboratory,Capital Medical University,Beijing 100026,China;Gynecology,Beijing Obstetrics and Gynecology Hospital,Capital Medical University,Beijing 100026,China)

机构地区：[1]首都医科大学附属北京妇产医院,检验科,北京100026 [2]首都医科大学附属北京妇产医院,妇科,北京100026

出　　处：《标记免疫分析与临床》2022年第9期1473-1475,1541,共4页Labeled Immunoassays and Clinical Medicine

基　　金：北京市属医院科研培育计划项目-脂质代谢物质谱定量检测及其在子痫前期预测中的应用(编号:PX2020060)。

摘　　要：目的探讨孕妇生殖道分泌物支原体的检测及药敏结果在妊娠期内的检测价值,为临床的诊疗提供可靠依据。方法使用丽珠支原体培养鉴定及药敏检测试剂盒对我院2021年1月至2022年3月就诊303例孕妇进行支原体培养鉴定及药敏检验。结果在303例受检孕妇中支原体感染118例(39.27%),其中单纯Uu感染为最多为102例(33.66%),单纯Mh感染4例(1.32%),Uu+Mh混合感染12例(3.96%)。单纯Uu感染、单纯Mh感染和Uu+Mh混合感染对强力霉素、美满霉素、交沙霉素均有很高的敏感率,而单纯Mh感染和Uu+Mh混合感染对克拉霉素、罗红霉素、阿奇霉素、氧氟沙星、左旋杀星和丝帕沙星有较高的耐药率。结论孕妇生殖道支原体感染率在40%左右,以单纯Uu感染为主。临床应根据支原体药敏实验进行精准治疗,首选治疗药物是强力霉素、美满霉素、交沙霉素。Objective To analyze the detection results of Mycoplasma in reproductive tract secretions of pregnant women and to evaluate the value of drug sensitivity results in pregnancy,so as to provide a reliable reference basis for the clinical diagnosis and treatment.Methods 303 pregnant women in our hospital from January,2021 to March,2022 were tested for mycoplasma culture and drug sensitivity by using Lizhu mycoplasma culture identification and drug sensitivity test kit.Results Among 303 pregnant women examined,118 cases(39.27%)were positive for mycoplasma infection,of which 102 cases(33.66%)were simple UU infection,4 cases(1.32%)were simple MH infection and 12 cases(3.96%)were mixed UU&MH infection.Simple UU infection,simple MH infection and UU&MH mixed infection had a high sensitivity to doxycycline,minocycline and josamycin,while simple MH infection and UU&MH mixed infection had a high resistance to clarithromycin,roxithromycin,azithromycin,ofloxacin,levosacin and sepafloxacin.Conclusion The infection rate of Mycoplasma genitalium in pregnant women is about 40%,mainly with simple UU infection.In clinical practices,a precise treatment should be carried out according to the experimental drug sensitivity of Mycoplasma.The preferred therapeutic drugs are doxycycline,minocycline and josamycin.

关 键 词：孕妇生殖道支原体感染 解脲支原体 人型支原体 药敏实验 

分 类 号：R375.3[医药卫生—病原生物学]