心周脂肪体积联合脂蛋白α、载脂蛋白B可诊断早期冠心病:基于MSCT测量  

Early diagnostic efficiency of coronary heart disease based on multi-slice spiral CT measurement of pericardial fat volume combined with lipoproteinαand apolipoprotein B detection

作　　者：王德芳 黄水英 林强[1] 杨金凤 WANG Defang;HUANG Shuiying;LIN Qiang;YANG Jinfeng(Department of Cardiovascular Medicine,Luzhou People's Hospital,Luzhou 646000,China)

机构地区：[1]泸州市人民医院心血管内科,四川泸州646000

出　　处：《分子影像学杂志》2022年第6期867-870,共4页Journal of Molecular Imaging

基　　金：四川省中医药管理局科研项目(2021MS374)。

摘　　要：目的探讨多层螺旋CT(MSCT)测量心周脂肪体积(PAT)联合脂蛋白α(Lp-α)、载脂蛋白B(Apo-B)检测在早期冠心病患者中的诊断评估价值。方法选取本院2020年3月~2022年4月收治的早期冠心病患者160例纳入观察组,再选取同期健康体检者110例为对照组,检测Lp-α、Apo-B水平及利用MSCT测量PAT,分析3项指标联合检测对冠心病的诊断评估价值。结果观察组PAT及Lp-α、水平均高于对照组(P<0.05);PAT及Lp-α、Apo-B水平与冠心病的发生呈正相关性(P<0.05);PAT及Lp-α、Apo-B水平与冠状动脉SYNTAX评分呈正相关性(P<0.05);ROC曲线显示:PAT及Lp-α、Apo-B联合诊断曲线下面积为0.920,高于各单项指标曲线下面积(P<0.05)。结论PAT及Lp-α、Apo-B水平在冠心病早期患者中升高,与冠心病的发生和病情程度密切相关,并对冠心病具有较高的诊断价值。Objective To explore the diagnostic value of multi-slice spiral CT(MSCT)measurement of pericardial adipose tissue(PAT)combined with lipoproteinα(Lp-α)and apolipoprotein B(Apo-B)detection in patients with early coronary heart disease.Methods A total of 160 patients with early coronary heart disease who were treated in our hospital from March 2020 to April 2022 were selected as the observation group.The 110 healthy subjects were selected during the same period.We detected the levels of Lp-αand Apo-B,and used MSCT to measure PAT to analyze the value of the combined detection of these three indicators in the diagnosis and evaluation of coronary heart disease.Results The levels of PAT,Lp-αin the observation group were significantly higher than those in the control group(P<0.05).Spearman correlation showed that the levels of PAT,Lp-αand Apo-B were positively correlated with the occurrence of coronary heart disease(P<0.05).PAT,Lp-α,Apo-B levels were positively correlated with coronary SYNTAX score(P<0.05).ROC curve showed that PAT,Lp-α,Apo-B levels combined diagnostic the area under the curve was 0.920,which was significantly higher than the area under the curve of each individual index(P<0.05).Conclusion The PAT,Lpαand Apo-B are elevated in patients with early coronary heart disease,which are closely related to the occurrence and severity of coronary heart disease.It has a high diagnostic value for coronary heart disease.

关 键 词：冠心病 多层螺旋CT 心周脂肪体积 脂蛋白Α 载脂蛋白B 诊断价值 

分 类 号：R541.4[医药卫生—心血管疾病]