α-氯代-α-乙酰基-γ-丁内酯的绿色合成工艺  

Green Synthesis Process ofα-Chloro-α-acetyl-γ-butyrolactone

作　　者：冯旋[1] FENG Xuan(Huazhong Pharmaceutical Co.,Ltd.,Xiangyang 441021,China)

机构地区：[1]华中药业股份有限公司,湖北襄阳441021

出　　处：《化工技术与开发》2022年第11期38-40,53,共4页Technology & Development of Chemical Industry

摘　　要：本文报道了α-氯代-α-乙酰基-γ-丁内酯的绿色合成工艺。以α-乙酰基-γ-丁内酯为原料,三氯异氰尿酸为氯代试剂,二氯甲烷为溶剂,制备得到α-氯代-α-乙酰基-γ-丁内酯。本工艺避免了传统的氯代工艺存在的毒性高、腐蚀性强、污染大等缺点,原子经济性高,符合绿色化学发展的趋势,有较好的工业应用前景。The green synthesis process ofα-chloro-α-acetyl-γ-butyrolactone was reported in this paper.It was synthesized fromα-acetyl-γ-butyrolactone with trichloroisocyanuric acid as chlorination reagent and dichloromethane as solvent.This process avoided the disadvantages of traditional chlorination process,such as high toxicity,strong corrosiveness and large pollution.The process had high atom economy,accorded with the development trend of green chemistry,and had good industrial application prospect.

关 键 词：α-氯代-α-乙酰基-γ-丁内酯 三氯异氰尿酸 Β-二羰基化合物 α-乙酰基-γ-丁内酯 氯代反应 

分 类 号：O623.624[理学—有机化学]