小檗胺在药用植物中的分布与药理活性  

Distribution and Pharmacological Activity of Berbamine in Medicinal Plants

作　　者：陈元 李思琪 陈紫葳 郭文欣 李旻辉 肖培根[4] CHEN Yuan;LI Si-qi;CHEN Zi-wei;GUO Wen-xin;LI Min-hui;XIAO Pei-gen(Inner Mongolia Medical University,Hohhot 010110,China;Inner Mongolia Hospital of Traditional Chinese Medicine,Hohhot 010020,China;Baotou Medical College,Baotou 014040,China;Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100193,China)

机构地区：[1]内蒙古医科大学,内蒙古呼和浩特010110 [2]内蒙古自治区中医医院,内蒙古呼和浩特010020 [3]包头医学院,内蒙古包头014040 [4]中国医学科学院北京协和医学院药用植物研究所,北京100193

出　　处：《中国现代中药》2022年第10期2018-2025,共8页Modern Chinese Medicine

基　　金：国家自然科学基金项目(38670277,30530860)。

摘　　要：小檗胺是提取自药用植物的天然小分子化合物,属双苄基异喹啉类生物碱,广泛分布于小檗科、罂粟科、防己科及毛茛科药用植物中,主要用于抗白血病等多种肿瘤,也可用于治疗心血管疾病、眼部疾病、免疫系统疾病、糖尿病肾病及抗纤维化等方面。对近年来小檗胺所分布的药用植物类群及药理作用研究进行综述,以期为小檗胺相关研究提供参考,为小檗属植物亲缘学的进一步研究提供依据。Berbamine,also known as bis-benzylisoquinoline alkaloid,is a low-molecular-weight compound from medicinal plants,particularly the Berberidaceae,Papaveraceae,Menispermaceae,and Ranunculaceae.It is used mainly for fighting leukemia and other cancers and is applicable to the treatment of cardiovascular diseases,eye diseases,immune system diseases,diabetic nephropathy,fibrosis,etc.This paper reviews the medicinal plants containing berbamine and pharmacological effects of it,which is expected to provide a reference for the research on berbamine and further research on pharmacophylogeny of Berberis plants.

关 键 词：小檗胺 地理分布 药理作用 药用植物亲缘学 

分 类 号：R282[医药卫生—中药学] R285[医药卫生—中医学]