超声造影评价糖尿病患者足拇短伸肌微循环的临床价值  

Clinical value of contrast-enhanced ultrasound in evaluating microcirculation of the extensor pollicis brevis in patients with diabetic mellitus

作　　者：颜富强 施迎迎 林金淼 黄珊珊 李美蓉[2] 蔡名利 吕国荣 YAN Fuqiang;SHI Yingying;LIN Jinmiao;HUANG Shanshan;LI Meirong;CAI Mingli;LV Guorong(Department of Ultrasound Medicine,Jinjiang Municipal Hospital,Fujian 362200,China)

机构地区：[1]福建省晋江市医院上海市第六人民医院福建医院超声医学科,362200 [2]福建省晋江市医院上海市第六人民医院福建医院内分泌科,362200 [3]泉州医学高等专科学校

出　　处：《临床超声医学杂志》2022年第11期837-840,共4页Journal of Clinical Ultrasound in Medicine

基　　金：泉州科技局计划项目(2022NS017)。

摘　　要：目的 应用超声造影(CEUS)评价糖尿病患者足拇短伸肌微循环的临床价值。方法 选取在我院内分泌科确诊的2型糖尿病患者30例,其中单纯糖尿病患者14例(DM组),2型糖尿病合并微血管病变16例(DM+MC组),另选同期健康志愿者25例作为正常组,应用CEUS测量各组足拇短伸肌的血流灌注情况,获取到达时间(AT)、造影剂自跗外侧动脉到足拇短伸肌的渡越时间(ΔAT)、峰值强度(PI)、增强强度(ΔPI)及基本强度(BI),比较各组上述参数的差异。绘制受试者工作特征(ROC)曲线分析各CEUS参数对糖尿病合并微血管病变的诊断效能。结果 各组PI、ΔPI、AT及ΔAT比较差异均有统计学意义(均P<0.05);其中PI及ΔPI两两比较差异均有统计学意义(均P<0.05),DM组与DM+MC组、正常组与DM+MC组AT和ΔAT比较差异均有统计学意义(均P<0.05)。各组BI比较差异无统计学意义。ROC曲线分析显示,各CEUS参数中以ΔAT、ΔPI对糖尿病合并微血管病变的诊断效能最佳(曲线下面积分别为0.989、0.954)。结论 应用CEUS可以评价糖尿病患者足拇短伸肌的微循环情况,其中ΔPI及ΔAT可为临床早期发现糖尿病合并微血管病变提供参考。Objective To evaluate the clinical value of contrast-enhanced ultrasound(CEUS) in evaluating microcirculation of the extensor pollicis brevis in patients with diabetic mellitus(DM).Methods Thirty patients with type 2DM diagnosed in the Department of endocrinology of our hospital were selected,including 14 cases of type 2 DM group and 16cases of type 2 DM with microangiopathy(DM+MC)group.25 healthy volunteers during the same period were selected as the normal control group.The blood perfusion of extensor pollicis brevis in each group was measured by CEUS,and the arrival time(AT),the time from the lateral tarsal artery to the extensor pollicis brevis(ΔAT),peak intensity(PI),enhancement intensity(ΔPI)and basic intensity(BI)were obtained and compared.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic efficacy of CEUS parameters for DM with microangiopathy.Results PI,ΔPI,AT and ΔAT were significantly different among the groups(all P<0.05).The difference between PI andΔPI in each group were statistically significant(all P<0.05).There were significant difference in AT andΔAT between DM group and DM+MC group,normal control group and DM+MC group(all P<0.05).There was no significant difference in BI among the groups.ROC curve analysis showed thatΔAT andΔPI of CEUS had the best diagnostic efficacy for DM with microangiopathy(the area under the curve were 0.989,0.954,respectively).Conclusion CEUS could evaluate the microcirculation of extensor pollicis brevis in patients with DM.The parametersΔAT andΔPI could provide reliable diagnostic information for the early detection of DM with microangiopathy.

关 键 词：超声检查 造影剂 糖尿病 微循环 骨骼肌 

分 类 号：R445.1[医药卫生—影像医学与核医学] R781.64[医药卫生—诊断学]