经颅低强度聚焦超声在中枢神经调控中的研究进展  

Research progress of transcranial low intensity focused ultrasound in central nervous system regulation

作　　者：臧金惠 郑禕婧 郑元义[1] ZANG Jinhui;ZHENG Yijing;ZHENG Yuanyi(Department of Ultrasound Medicine,the Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200233,China)

机构地区：[1]上海交通大学附属第六人民医院超声医学科上海超声医学研究所,上海市200233

出　　处：《临床超声医学杂志》2022年第11期864-866,共3页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学基金重点项目(82030050);国家自然科学基金重点国际(地区)合作研究项目(81720108023);上海市科技创新行动计划医学创新研究专项重点项目(21Y21901100)。

摘　　要：神经调控技术为神经回路功能障碍所致疾病的治疗提供了新的思路,经颅低强度聚焦超声作为一项新的技术,与经颅磁刺激和经颅电刺激相比,其穿透能力更强,且可聚焦于毫米级区域,实现更为精准的神经调控。本文以特发性震颤、帕金森病、阿尔茨海默病及抑郁症为例,对近年来经颅低强度聚焦超声在中枢神经调控中的研究进展进行综述。Neuromodulation technology has provided new ideas for the treatment of diseases caused by dysfunction of neural circuits.As a new technology,transcranial low intensity focused ultrasound has a better penetration ability compared with transcranial magnetic stimulation and transcranial electrical stimulation,it can focus on the millimeter scale region to achieve more precise neuromodulation.Taking essential tremor,Parkinson’s disease,Alzheimer’s disease and depressive disorder as examples,this paper reviews the research progress of transcranial low intensity focused ultrasound in the treatment application and biological mechanism in recent years.

关 键 词：超声检查 低强度 经颅 神经调节 中枢神经系统 

分 类 号：R445.1[医药卫生—影像医学与核医学]