Rice OsUBR7 modulates plant height by regulating histone H2B monoubiquitination and cell proliferation  

作　　者：Yangyi Zheng Sensen Zhang Yanqiu Luo Fuquan Li Jiantao Tan Bin Wang Zhe Zhao Huifang Lin Tingting Zhang Jianhong Liu Xupeng Liu Jingxin Guo Xianrong Xie Letian Chen Yao-Guang Liu Zhizhan Chu 

机构地区：[1]State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources,College of Life Sciences,South China Agricultural University,Guangzhou 510642,China [2]Guangdong Laboratory for Lingnan Modern Agriculture,Guangzhou 510642,China [3]Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms,South China Agricultural University,Guangzhou 510642,China

出　　处：《Plant Communications》2022年第6期251-266,共16页植物通讯（英文）

基　　金：supported by the Major Program of Guangdong Basic and Applied Basic Research(2019B030302006);the National Natural Science Foundation of China(31921004,31871533,and 31760300);the Laboratory of Lingnan Modern Agriculture Project(NT2021002);the Guangdong Basic and Applied Basic Research Foundation(2019A1515010230).

摘　　要：Plant height is an important agronomic trait for lodging resistance and yield.Here,we report a new plantheight-related gene,OsUBR7 in rice(Oryza sativa L.);knockout of OsUBR7 caused fewer cells in internodes,resulting in a semi-dwarf phenotype.OsUBR7 encodes a putative E3 ligase containing a plant homeodomain finger and a ubiquitin protein ligase E3 component N-recognin 7(UBR7)domain.OsUBR7 interacts with histones and monoubiquitinates H2B(H2Bub1)at lysine148 in coordination with the E2 conjugase OsUBC18.OsUBR7 mediates H2Bub1 at a number of chromatin loci for the normal expression of target genes,including cell-cycle-related and pleiotropic genes,consistent with the observation that cell-cycle progression was suppressed in the osubr7 mutant owing to reductions in H2Bub1 and expression levels at these loci.The genetic divergence of OsUBR7 alleles among japonica and indica cultivars affects their transcriptional activity,and these alleles may have undergone selection during rice domestication.Overall,our results reveal a novel mechanism that mediates H2Bub1 in plants,and UBR7 orthologs could be utilized as an untapped epigenetic resource for crop improvement.

关 键 词：histone H2B monoubiquitination E3 ligase UBR7 plant height RICE 

分 类 号：S511[农业科学—作物学]